MAP2K5 Antikörper (pSer311, pThr315)

Produktnummer ABIN361510

Produktdetails anti-MAP2K5 Antikörper

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Bindungsspezifität: pSer311, pThr315

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: Specific for the ~49k MEK5 protein phosphorylated at Ser311, Thr315. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.

Kreuzreaktivität: Ratte (Rattus)

Homologie: bovine, canine, chicken, human, mouse, non-human primates, Xenopus, zebra fish

Aufreinigung: Antigen Affinity Purified from Pooled Serum

Immunogen: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser311/Thr315 conjugated to KLH

Anwendungsinformationen

Applikationshinweise: Recommended Dilution: WB: 1:1000 Quality Control: Western blots performed on each lot.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 100 μL in 10 mM HEPES (  pH 7.5), 150 mM NaCl, 100 μg per ml BSA and 50 % glycerol.

Lagerung: -20 °C

Details zu MAP2K5

Target: MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5 (MAP2K5))

Andere Bezeichnung: MAP2K5 (MAP2K5 Produkte)

Synonyme: Mek5 antikoerper, HsT17454 antikoerper, MAPKK5 antikoerper, MEK5 antikoerper, PRKMK5 antikoerper, AI324775 antikoerper, AI428457 antikoerper, Mapkk5 antikoerper, Prkmk5 antikoerper, fb73f02 antikoerper, wu:fb73f02 antikoerper, zgc:172137 antikoerper, ARABIDOPSIS THALIANA MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5 antikoerper, ATMAP2K_ALPHA antikoerper, ATMEK5 antikoerper, ATMKK5 antikoerper, MAP KINASE KINASE 5 antikoerper, MAP kinase kinase 5 antikoerper, MAP2K_A antikoerper, mitogen activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 antikoerper, mitogen-activated protein kinase kinase 5 L homeolog antikoerper, MAP kinase kinase 5 antikoerper, Map2k5 antikoerper, MAP2K5 antikoerper, map2k5 antikoerper, map2k5.L antikoerper, MKK5 antikoerper

Hintergrund: MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004). Anti-Phospho-Ser311, Thr315 MEK5 Western blot of rat testes lysate showing specific labeling of the ~49k MEK5 protein (Control). Immunolabeling is blocked by preadsorption with the phospho-peptide used as antigen (Peptide) but not by the corresponding dephospho-peptide (not shown).

Molekulargewicht: '49 kDa

Gen-ID: 31068

UniProt: Q62862

Pathways: MAPK Signalweg, Neurotrophin Signalübertragung