LRP2 Antikörper

Produktnummer ABIN360955

Dieses Maus Monoklonal-Antikörper erkennt spezifisch LRP2 in IHC (p) und IF. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.

Kurzübersicht für LRP2 Antikörper (ABIN360955)

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LRP2 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)

Klon: CD7D5

Produktdetails anti-LRP2 Antikörper

Spezifität: This antibody recognizes Megalin/gp330.

Aufreinigung: Protein G Chromatography

Immunogen: Purified Human Megalin.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile water to a concentration of 0.1-1.0 mg/mL.

Buffer: PBS, pH 6.0 without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C.

Details zu LRP2

Target: LRP2 (Low Density Lipoprotein Receptor-Related Protein 2 (LRP2))

Andere Bezeichnung: LRP2

Hintergrund: Megalin, also called Lipoprotein receptor-related protein-2 (LRP2) or glycoprotein 330, is a 600- kDa transmembrane protein belonging to the LDL-receptor family. Members of this receptor family are characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. Megalin was first discovered in 1982 as the pathogenic antigen of Heymann nephritis. The complete cDNA sequences have been characterized for rat and human Megalin. The protein contains a single transmembrane domain, is known to act as an endocytic receptor and is expressed primarily on the apical membrane domain of epithelial cells. Both the protein and its mRNA have been identified in human parathyroid cells, placental cytotrophoblasts and epididymal epithelial cells. The protein is also expressed in mammary epithelia, thyroid follicular cells, yolk sacs, the ciliary body of the eye, the intestinal brush border, the male reproductive tract, uterus and oviduct, and gallbladder epithelium. In addition, immortalised foetal rat alveolar pretype II cells, adult rat type II pneumocytes and human type II cells have all been reported to express megalin. It has been proposed that in adult lung megalin may be important in supplying vitamin E to type II pneumocytes. Specifically, Megalin mediates the uptake of apolipoprotein J, which is a binding protein for the beta-Amyloid peptide, a peptide implicated in Alzheimer's disease. It is also involved in renal uptake of Angiotensin and the reabsorption of various molecules including calcium, vitamin B12 and vitamin D.Synonyms: Glycoprotein 330, LRP-2, Low-density lipoprotein receptor-related protein 2, Megalin

Gen-ID: 4036

NCBI Accession: NP_004516

UniProt: P98164

Pathways: Metabolism of Steroid Hormones and Vitamin D, Thyroid Hormone Synthesis, Hormone Transport