GAS6 Antikörper

Produktnummer ABIN360889

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch GAS6 in WB. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für GAS6 Antikörper (ABIN360889)

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser GAS6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 6J2

Produktdetails anti-GAS6 Antikörper

Spezifität: The monoclonal antibody detects Gas6.

Aufreinigung: Protein A/G Affinity Chromatography

Immunogen: Purified Mouse Recombinant Gas6

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 200 μL sterile PBS and the final concentration is 500 μg/mL.

Buffer: 0.2 μm filtered PBS without preservatives or stabilizers

Konservierungsmittel: Without preservative

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GAS6

Target: GAS6 (Growth Arrest-Specific 6 (GAS6))

Andere Bezeichnung: GAS6 / AXLLG

Hintergrund: Gas6 (Growth Arrest Specific 6) is one of six structurally unrelated proteins that are secreted by a wide variety of cell types in response to growth arrest. Gas6 and the structurally related Protein S are vitamin K-dependent and have an extensively gamma-carboxylated N-terminal Gla domain, four EGF like repeats, and a C-terminal region with homology to steroid hormone binding globulin (SHBG). Human Gas6 is a 75 kDa protein that shares 77 % -79 % aa sequence identity with mouse and rat Gas6. Alternate splicing generates isoforms that lack the Gla domain and/or the spacer between the EGF-like and SHBG regions. Gas6 binds and induces signaling through the receptor tyrosine kinases Axl, Dtk, and Mer. Human Gas6 interacts with both mouse and rat orthologs of these receptors. The full length isoform may be cleaved, resulting in release of the free SHBG region which can independently activate Axl. Shed soluble forms of Axl and Mer bind Gas6 and function as decoy receptors.Synonyms: AXL receptor tyrosine kinase ligand, GAS-6, Growth arrest-specific protein 6

Gen-ID: 2621

NCBI Accession: NP_000811

UniProt: Q14393

Pathways: RTK Signalweg, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response