Decorin Antikörper

Produktnummer ABIN360879

Der Ratte Monoklonal anti-Decorin Antikörper (Klon 9A38) (ABIN360879) detektiert spezifisch Decorin in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für Decorin Antikörper (ABIN360879)

Target: Decorin (DCN)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Decorin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 9A38

Produktdetails anti-Decorin Antikörper

Spezifität: This antibody detects Mouse Decorin in Western blotting.

Aufreinigung: Protein A/G affinity chromatography

Immunogen: Recombinant Decorin

Isotyp: IgG2

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/500 - 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 0.2 mL sterile PBS and the final concentration is 0.5 mg/mL.

Buffer: 0.2 μm filtered PBS solution

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Decorin

Target: Decorin (DCN)

Andere Bezeichnung: Decorin

Hintergrund: Secreted chondroitin/dermatan sulfate proteoglycan belonging to the class I small leucine-rich proteoglycan family (SLRP). All SLRP family members are characterized by the Nterminal and C terminal cysteine rich regions, which flank the central region containing 1012 tandem leucinerich repeats. In mouse Decorin, the glycosaminoglycan chain is Olinked to Ser34 in the Nterminal disulfide bridged loop. Decorin binds to fibronectin, TGFβ, type I and type II collagen. The binding of Decorin to these molecules is mediated via the core protein. Decorin plays a role in maintaining collagen fibrillogenesis. Depending on the cell context, Decorin can either block or augment the bioactivity of TGFβ Decorin induces growth suppression by activation of a signaling pathway that culminates in the blockade of the cell cycle machinery. Decorin can also induce fibroblast cytoskeletal and signalling changes that results in an increased cell migration (1 2).Synonyms: Bone proteoglycan II, DCN, PG-S2, PG40, SLRR1B

Gen-ID: 13179

NCBI Accession: NP_001177380

UniProt: P28654

Pathways: Glycosaminoglycan Metabolic Process