SNCAIP Antikörper (C-Term)

Produktnummer ABIN359008

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch SNCAIP in WB und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für SNCAIP Antikörper (C-Term) (ABIN359008)

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SNCAIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SNCAIP Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody reacts to Synphilin-1 (SNCAIP).

Aufreinigung: Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide in the C-terminal region of human Synphilin-1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/50 - 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu SNCAIP

Target: SNCAIP (Synuclein, alpha Interacting Protein (SNCAIP))

Andere Bezeichnung: Synphilin 1 / SNCAIP

Hintergrund: Parkinson is the second most common neurodegenerative disease after Alzheimers. About 1 percent of people over the age of 65 and 3 percent of people over the age of 75 are affected by the disease. The mutation is the most common cause of Parkinson disease identified to date. Synuclein alpha interacting protein (Synphilin-1) contains several protein-protein interaction domains and interacts with alpha synuclein in neurons. Mutations of SNCAIP have been linked to Parkinson disease. The amino acid sequence of synphilin-1 shows extensive homology with its human counterpart, especially in regions containing ankyrin-like motifs and the coiled-coil domain. Expression of mouse synphilin-1 in tissues is similar to its human counterpart. Synphilin-1 has an important role in the formation of aggregates and cytotoxicity in Parkinson disease and that Dorfin may be involved in the pathogenic process by ubiquitylation of synphilin-1. Role of synphilin-1 in synaptic function and protein degradation and in the molecular mechanisms leading to neurodegeneration in Parkinson diseaseSynonyms: Alpha-synuclein-interacting protein, Sph1, Synphilin-1

Gen-ID: 9627

NCBI Accession: NP_005451

UniProt: Q9Y6H5