CRY2 Antikörper (C-Term)

Produktnummer ABIN358614

Produktdetails anti-CRY2 Antikörper

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRY2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody reacts to CRY2.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human CRY2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western blotting: 1/100 - 1/500. Immunohistochemistry: 1/50 - 1/100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu CRY2

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Andere Bezeichnung: Cryptochrome-2 (CRY2 Produkte)

Synonyme: Cry2 antikoerper, Cry antikoerper, GB10211 antikoerper, CRY2 antikoerper, AT-PHH1 antikoerper, ATCRY2 antikoerper, CRYPTOCHROME 2 APOPROTEIN antikoerper, F19P19.14 antikoerper, F19P19_14 antikoerper, FHA antikoerper, PHH1 antikoerper, cryptochrome 2 antikoerper, HCRY2 antikoerper, PHLL2 antikoerper, AV006279 antikoerper, D130054K12Rik antikoerper, gCry2 antikoerper, cryptochrome circadian regulator 2 antikoerper, cryptochrome 2 antikoerper, cryptochrome Cry2 antikoerper, cryptochrome circadian clock 2 antikoerper, cryptochrome 2 (photolyase-like) antikoerper, CRY2 antikoerper, Cry2 antikoerper, cry2 antikoerper, LOC100502533 antikoerper

Hintergrund: Various biochemical, physiological and behavioural processes display circadian rhythms controlled by an internal biological clock. The central gears driving this clock appear to be composed of an autoregulatory transcription/posttranslation-based feedback loop. Cryptochrome 1 (CRY1) and 2 (CRY2) are DNA-binding flavoproteins that bear some homology to blue-light receptors and photolyases. In Drosophila, CRY is a photoreceptor for the circadian clock where it binds to the clock component TIM in a light-dependent fashion and blocks its function. Mammalian CRY1 and CRY2 function via light-independent interactions with circadian genes CLOCK and BMAL1, as well as with PER1, PER2, and TIM. They seem to act as light-independent components of the circadian clock and likely regulate Per1 transcriptional cycling via interactions with both the activator and its feedback inhibitors. Mutant mice not expressing the Cry1 or Cry2 protein display accelerated and delayed periodicity of locomotor activity, respectively. It appears that the combination of both proteins working together is essential to synchronize the organism to circadian phases. A critical balance between Cry1 and Cry2 is required for proper clock function, in complete darkness, double-mutant mice present with instantaneous arrhythmicity, indicating the absence of an internal circadian clock.Synonyms: CRY2, KIAA0658

Gen-ID: 1408

NCBI Accession: NP_001120929

UniProt: Q49AN0

Pathways: Response to Water Deprivation, Protein targeting to Nucleus