CRY2 Antikörper (N-Term)

Produktnummer ABIN2784909

Produktdetails anti-CRY2 Antikörper

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte, Meerschweinchen, Pferd, Kaninchen, Rind (Kuh), Schaf, Hund, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CRY2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Sequenz: IELNGQKPPL TYKRFQAIIS RMELPKKPVG LVTSQQMESC RAEIQENHDE

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 86%

Produktmerkmale: This is a rabbit polyclonal antibody against CRY2. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CRY2

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 593 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-CRY2 Antikörper (ABIN2784909)

Currie, Doherty, Sillar: "Deep-brain photoreception links luminance detection to motor output in Xenopus frog tadpoles." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 21, pp. 6053-8, (2016) (PubMed).

Details zu CRY2

Target: CRY2 (Cryptochrome 2 (Photolyase-Like) (CRY2))

Andere Bezeichnung: CRY2 (CRY2 Produkte)

Synonyme: Cry2 antikoerper, Cry antikoerper, GB10211 antikoerper, CRY2 antikoerper, AT-PHH1 antikoerper, ATCRY2 antikoerper, CRYPTOCHROME 2 APOPROTEIN antikoerper, F19P19.14 antikoerper, F19P19_14 antikoerper, FHA antikoerper, PHH1 antikoerper, cryptochrome 2 antikoerper, HCRY2 antikoerper, PHLL2 antikoerper, AV006279 antikoerper, D130054K12Rik antikoerper, gCry2 antikoerper, cryptochrome circadian regulator 2 antikoerper, cryptochrome 2 antikoerper, cryptochrome Cry2 antikoerper, cryptochrome circadian clock 2 antikoerper, cryptochrome 2 (photolyase-like) antikoerper, CRY2 antikoerper, Cry2 antikoerper, cry2 antikoerper, LOC100502533 antikoerper

Hintergrund: CRY2 is a blue light-dependent regulator of the circadian feedback loop.CRY2 inhibits CLOCK NPAS2-ARNTL E box-mediated transcription. CRY2 acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity.CRY2 has no photolyase activity. CRY2 is capable of translocating circadian clock core proteins such as PER proteins to the nucleus.CRY2 may inhibit CLOCK NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL.
Alias Symbols: FLJ10332, HCRY2, KIAA0658, PHLL2
Protein Interaction Partner: MTUS2, PDE9A, CTBP1, UBC, FBXL3, FBXL21, BTRC, CUL1, SKP1, ATXN1, Csnk1e, PER3, PER2, PER1, PPP5C, TTC1, CRY2, TIMELESS,
Protein Size: 593

Molekulargewicht: 67 kDa

Gen-ID: 1408

NCBI Accession: NM_021117, NP_066940

UniProt: Q49AN0

Pathways: Response to Water Deprivation, Protein targeting to Nucleus