SIGMAR1 Antikörper (Middle Region)

Produktnummer ABIN357897

Dieser Anti-SIGMAR1 Antikörper ist ein Kaninchen Polyklonal Antikörper zur Detektion von SIGMAR1 in WB und EIA. Geeignet für Human.

Kurzübersicht für SIGMAR1 Antikörper (Middle Region) (ABIN357897)

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SIGMAR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-SIGMAR1 Antikörper

Bindungsspezifität: Middle Region

Spezifität: This antibody detects OPRS1 (Center).

Aufreinigung: Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the Center region of human OPRS1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1,000. Western Blot: 1/50-1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at-20 °C for longer.

Details zu SIGMAR1

Target: SIGMAR1 (sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1))

Andere Bezeichnung: SIGMAR1 / OPRS1

Hintergrund: The sigma (s) receptor (sigma-1R, Oprs1 protein, opioid receptor sigma 1) and its agonists are implicated in a variety of cellular functions, biological processes and diseases, including cancer biology, psychosis, regulation of neurotransmitter function, motor, endocrine and immune systems. Two sigma receptors, -1 and -2 are presently known and classified based on their ability to bind a variety of ligands. The sigma-1 receptor interacts with a variety of psychotomimetic drugs, including cocaine and amphetamines. It is distinct from any known receptor class and lacks significant homology to known mammalian proteins but possesses some homology with fungal sterol isomerases. The predicted structure of this 25 kDa protein depicts two transmembrane domains with both N- and C-terminal tails residing in the cytoplasm. The sigma-1 receptor is highly expressed in the central nervous system, heart, ovary, kidney, testes, liver, placenta and embryonic stem cells. Both sigma receptors are also highly expressed in tumor cell lines from various tissues, including small- and non-small-cell lung carcinoma, large-cell carcinoma, renal carcinoma, colon carcinoma, sarcoma, brain tumors, breast cancer, emlanoma, glioblastoma, neuroblastoma and prostate cancer. The exact mechanism how sigma-1R affects cancer biology is not known. Some hypotheses include modulation of ion channel activity, cytoskeletal proteins such as ankyrin, intracellular calcium levels, or sphingolipid levels1. Recent evidence also suggests that sigma-1R is important in the compartmentalization / transport of ER-synthesized lipids. Two polymorphisms of the sigma-1R gene, which decrease expression of the gene, are associated with occurrence of Alzheimer's disease.Synonyms: AAG8, Aging-associated gene 8 protein, SIG-1R, SR-BP, SR31747-binding protein, SRBP, Sigma 1-type opioid receptor, Sigma non-opioid intracellular receptor 1, Sigma1-receptor, Sigma1R

Molekulargewicht: 25128 Da

Gen-ID: 10280, 9606

UniProt: Q99720

Pathways: SARS-CoV-2 Protein Interaktom