GRM8 Antikörper (C-Term)

Produktnummer ABIN357164

Der Kaninchen Polyklonal Anti-GRM8-Antikörper wurde für WB und EIA validiert. Er ist geeignet, GRM8 in Proben von Human und Maus zu detektieren.

Kurzübersicht für GRM8 Antikörper (C-Term) (ABIN357164)

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-GRM8 Antikörper

Bindungsspezifität: C-Term

Spezifität: This antibody detects Metabotropic Glutamate Receptor 8 (GRPRC1H) at C-term.

Aufreinigung: Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

Immunogen: This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GRPRC1H.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: ELISA 1: 1,000Western blot 1: 100 - 1: 500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.

Details zu GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Andere Bezeichnung: mGluR8 / GRM8

Hintergrund: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors,that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.Synonyms: GPRC1H, Metabotropic glutamate receptor 8

Molekulargewicht: 101740 Da

Gen-ID: 2918, 9606

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane