GRM8 Antikörper (AA 841-890)

Produktnummer ABIN1533293

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch GRM8 in WB, IHC, ELISA und IF. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für GRM8 Antikörper (AA 841-890) (ABIN1533293)

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRM8 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-GRM8 Antikörper

Bindungsspezifität: AA 841-890

Verwendungszweck: mGluR-8 Antibody

Spezifität: MGluR-8 Polyclonal Antibody detects endogenous levels of mGluR-8 protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Reinheit: > 95 %

Immunogen: The antiserum was produced against synthesized peptide derived from human mGluR8. AA range:841-890

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000.. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu GRM8

Target: GRM8 (Glutamate Receptor, Metabotropic 8 (GRM8))

Andere Bezeichnung: mGluR8

Hintergrund:

Synonyms: GRM8, GPRC1H, MGLUR8, Metabotropic glutamate receptor 8, mGluR8

Background: glutamate metabotropic receptor 8(GRM8) Homo sapiens L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been d

Gene Name: GRM8

Protein Name: Metabotropic glutamate receptor 8

Molekulargewicht: 101 kDa

Gen-ID: 2918

OMIM: 601116

UniProt: O00222

Pathways: cAMP Metabolic Process, Synaptic Membrane