Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GCAP1 Antikörper (C-Term)

Dieses Anti-GCAP1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von GCAP1 in WB, IHC (p) und EIA. Geeignet für Human.
Produktnummer ABIN357117

Kurzübersicht für GCAP1 Antikörper (C-Term) (ABIN357117)

Target

Alle GCAP1 (GUCA1A) Antikörper anzeigen
GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

Reaktivität

  • 20
  • 18
  • 17
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 34
  • 1
Kaninchen

Klonalität

  • 34
  • 1
Polyklonal

Konjugat

  • 12
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GCAP1 Antikörper ist unkonjugiert

Applikation

  • 29
  • 17
  • 13
  • 13
  • 10
  • 5
  • 3
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Bindungsspezifität

    • 15
    • 9
    • 5
    • 3
    • 1
    • 1
    • 1
    C-Term

    Spezifität

    This antibody detects GCAP1 at C-term.

    Aufreinigung

    Protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS

    Immunogen

    This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human GCAP1.

    Isotyp

    Ig Fraction
  • Applikationshinweise

    ELISA 1: 1,000. Western blot 1: 100 - 1: 500. Immunohistochemistry 1: 50 - 1: 100.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    0.25 mg/mL

    Buffer

    PBS with 0.09 % (W/V) sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C/-20 °C

    Informationen zur Lagerung

    Store the antibody at 2 - 8 °C up to one month or (in aliquots) at -20 °C for longer.
  • Target

    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

    Andere Bezeichnung

    GCAP1 / GUCA1A

    Hintergrund

    Guanylate cyclase-activating protein is a l Ca(2+)-binding protein that upregulates synthesis of cGMP in photoreceptors. The known mammalian GCAPs are more than 90 % similar, consisting of 201 to 205 amino acids, and containing 3 identically conserved Ca(2+)-binding sites. The GUCA1A gene, also termed GCAP1, is transcribed into a single 1.7-kb mRNA species detectable only in the retina. In a 4-generation British family with typical clinical features of autosomal dominant cone dystrophy a tyr99-to-cys mutation) in the GUCA1A gene has been identified. Another family with a pro50-to-leu mutation in GUCA1A demonstrated phenotypic variability ranging from mild photophobia to rod-cone dystrophy. The mutant protein could activate guanylate cyclase 1 (GUCY2D) and displayed similar calcium sensitivity to wildtype protein. However, there was a marked increase in the susceptibility to protease degradation and a reduction in the thermal stability of the pro50-to-leu mutation, which may depress cellular concentration and thereby contribute to retinal cell mortality.Synonyms: C6orf131, GUCA1, Guanylate cyclase activator 1A, Guanylyl cyclase-activating protein 1

    Molekulargewicht

    22774 Da

    Gen-ID

    2978, 9606

    UniProt

    P43080

    Pathways

    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
Sie sind hier:
Chat with us!