Myc Tag (AA 423-435) Antikörper

Details zu Produkt Nr. ABIN351513, Anbieter: Anmelden zum Anzeigen
Antigen
  • MRTL
  • MYCC
  • bHLHe39
  • c-Myc
  • ARC
  • B430311C09Rik
  • MYC
  • NOP
  • Nop30
  • MYC proto-oncogene, bHLH transcription factor
  • nucleolar protein 3 (apoptosis repressor with CARD domain)
  • MYC
  • Nol3
Epitop
AA 423-435
56
20
18
9
6
4
2
2
2
2
1
1
Reaktivität
Tag
211
58
14
12
6
5
3
1
1
Wirt
Maus
166
64
20
17
6
5
3
1
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
28
24
15
9
5
5
4
4
4
4
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
239
118
94
69
50
39
36
35
22
7
6
5
5
4
4
4
3
3
3
2
1
1
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Marke IHC-plus™
Immunogen Synthetic peptide sequence (AEEQKLISEEDLL) corresponding to the C-terminal region of human c-myc. Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%), Orangutan, Monkey, Marmoset, Tamarin (92%), Rat, Sheep, Hamster, Panda, Dog, Horse (85%).

Type of Immunogen: Synthetic peptide
Klon 9E10
Isotyp IgG1
Spezifität The antibody 9E10 may be used to detect the c-Myc tag. The c-myc gene (8q24 on human chromosome) is the cellular homologue of the v-myc gene originally isolated from an avian myelocytomatosis virus. The c-Myc protein is a transcription factor (nuclear localization). c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin-dependent kinase, ERK2 and C-Jun N-terminal Kinase (JNK) in cell proliferation and cell cycle regulation. In normal cells the expression of c-Myc is tightly regulated but in human cancers c-Myc is frequently deregulated. c-Myc is also essential for tumor cell development in vasculogenesis and angiogenesis that distribute blood throughout the cells
Homologie Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%) Orangutan, Monkey, Marmoset, Tamarin (92%) Rat, Sheep, Hamster, Panda, Dog, Horse (85%).
Reinigung Protein G purified
Substanzklasse Tag
UniProt P01106
Applikationshinweise Approved: Flo (1 - 5 μg/mL), IHC-P (10 μg/mL), IP (1 - 5 μg/mL), WB (0.5 - 2 μg/mL)

Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody,
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer PBS, 15 mM sodium azide, approx, pH 7.4.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung +4°C or -20°C, Avoid repeated freezing and thawing.
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Myc Tag (AA 423-435) antibody (ABIN351513) Human Liver (formalin-fixed, paraffin-embedded) stained with c-Myc antibody ABIN35151...
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