GPR143 Antikörper (4th Cytoplasmic Domain)

Produktnummer ABIN350534

Der Kaninchen Polyklonal Anti-GPR143-Antikörper wurde für WB und IHC validiert. Er ist geeignet, GPR143 in Proben von Human zu detektieren.

Kurzübersicht für GPR143 Antikörper (4th Cytoplasmic Domain) (ABIN350534)

Target: GPR143 (G Protein-Coupled Receptor 143 (GPR143))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GPR143 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-GPR143 Antikörper

Bindungsspezifität: 4th Cytoplasmic Domain

Verwendungszweck: Rabbit antibody to OA1

Spezifität: Specific for OA1.

Kreuzreaktivität: Human

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from the 4th cytoplasmic domain of human OA1 conjugated to blue carrier protein was used as the antigen.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. A concentration of 10-50,micro,g,ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu GPR143

Target: GPR143 (G Protein-Coupled Receptor 143 (GPR143))

Andere Bezeichnung: OA1

Hintergrund: Ocular albinism type 1 protein is a conserved integral membrane protein with seven transmembrane domains. It is expressed in the eye and epidermal melanocytes. FUNCTION: Not known, binds heterotrimeric G proteins. SUBCELLULAR LOCATION: Melanosome membrane, Multi-pass membrane protein. Note: Targeted to intracellular organelles namely the melanosomes in pigment cells. TISSUE SPECIFICITY: Exclusively expressed in pigment cells. DISEASE: Defects in GPR143 are the cause of ocular albinism type 1 (OA1), also known as Nettleship-Falls type ocular albinism. OA1 is an X-linked disorder characterized by severe impairment of visual acuity retinal hypopigmentation and the presence of macromelanosomes.

UniProt: P51810