DRAM Antikörper (AA 160-210)

Produktnummer ABIN350295

Dieses Anti-DRAM-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von DRAM in WB und IHC. Geeignet für Human.

Kurzübersicht für DRAM Antikörper (AA 160-210) (ABIN350295)

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DRAM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-DRAM Antikörper

Bindungsspezifität: AA 160-210

Verwendungszweck: Rabbit antibody to DRAM

Spezifität: Specific for DRAM.

Kreuzreaktivität: Human, Maus, Ratte

Kreuzreaktivität (Details): Other species not yet tested.

Aufreinigung: IgG

Immunogen: A synthetic peptide from AA 160-210 of human DRAM conjugated to blue carrier protein has been used as the antigen. The antigen shares 85% identity with mouse's and rat's.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC WB. Use at a concentration of 10-50 μg,ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Reconstitute in 500 µL of sterile water. Centrifuge to remove any insoluble material.

Handhabung: Avoid freeze and thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu DRAM

Target: DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))

Andere Bezeichnung: DRAM

Hintergrund: This gene is regulated as part of the p53 tumor suppressor pathway. The gene encodes a lysosomal membrane protein that is required for the induction of autophagy by the pathway. Decreased transcriptional expression of this gene is associated with various tumors. This gene has a pseudogene on chromosome 4. FUNCTION: Lysosomal modulator of autophagy that plays a central role in p53/TP53-mediated apoptosis. Not involved in p73/TP73-mediated autophagy. SUBCELLULAR LOCATION: Lysosome membrane, Multi-pass membrane protein. INDUCTION: By p53/TP53 and p73/TP73. Directly activated by p53/TP53. Significantly down-regulated in tumor cell lines by methylation-dependent transcriptional silencing.

UniProt: Q8N682