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DRAM Antikörper (N-Term)

DRAM1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6990614
  • Target Alle DRAM (DRAM1) Antikörper anzeigen
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Bindungsspezifität
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 30-80, N-Term
    Reaktivität
    • 17
    • 7
    • 7
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 17
    Kaninchen
    Klonalität
    • 17
    Polyklonal
    Konjugat
    • 13
    • 2
    • 1
    • 1
    Dieser DRAM Antikörper ist unkonjugiert
    Applikation
    • 12
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Aufreinigung
    DRAM Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Anti-DRAM antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human DRAM. The immunogen is located within amino acids 30-80 of DRAM.
    Isotyp
    IgG
    Top Product
    Discover our top product DRAM1 Primärantikörper
  • Applikationshinweise
    WB: 1-2 μ,g/mL, IF: 20 μ,g/mL, IHC: 2-2.5 μ,g/mL.

    Antibody validated: Western Blot in human mouse and rat samples, Immunofluorescence and Immunohistochemistry in human and mouse samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    DRAM Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    DRAM antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • Target
    DRAM (DRAM1) (DNA-Damage Regulated Autophagy Modulator 1 (DRAM1))
    Andere Bezeichnung
    DRAM (DRAM1 Produkte)
    Synonyme
    DRAM1 antikoerper, DRAM antikoerper, 1200002N14Rik antikoerper, Dram antikoerper, dram antikoerper, DNA damage regulated autophagy modulator 1 antikoerper, DNA-damage regulated autophagy modulator 1 antikoerper, DNA damage regulated autophagy modulator 1 L homeolog antikoerper, DRAM1 antikoerper, Dram1 antikoerper, dram1.L antikoerper
    Hintergrund
    DRAM Antibody: Damage-regulated autophagy modulator (DRAM) is a p53 target gene encoding a lysosomal protein that induces autophagy, a process that degrades cytosolic proteins and organelles. It has been suggested that activation of DRAM by p53 is simultaneous to the activation by p53 of one or more proapoptotic genes such as PUMA, Bax, etc., and that the signaling pathways regulated by these genes together promote a full cell death response. By itself, DRAM cannot induce apoptosis, but the fact that it is inactivated in certain cancers highlights the importance of DRAM and suggests that autophagy may play a more important role in cancer than initially suspected. At least two different isoforms of DRAM are known to exist.
    Molekulargewicht
    Predicted: 14kD, 26kD

    Observed: 14 kD, 26kD kDa
    Gen-ID
    55332
    UniProt
    Q8N682
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