SERPINB2 Antikörper (Internal Region)

Produktnummer ABIN349627

Hersteller Produkt- Nr.: 600-401-b22

Der Kaninchen Polyklonal Anti-SERPINB2-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, SERPINB2 in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für SERPINB2 Antikörper (Internal Region) (ABIN349627)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-SERPINB2 Antikörper

Bindungsspezifität: Internal Region

Hersteller Produkt- Nr.: 600-401-b22

Hersteller: Rockland

Verwendungszweck: Plasminogen Activator Inhibitor 2 Antibody

Kreuzreaktivität (Details): This affinity-purified antibody is directed against human PAI-2 protein.

Produktmerkmale: Synonyms: rabbit anti-PAI-2 antibody, rabbit anti-plasminogen activator inhibitor 2 antibody, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2, Serpin B2, serpin peptidase inhibitor, PAI2, PLANH2

Aufreinigung: The product was affinity purified from monospecific antiserum by immunoaffinity purification.

Sterilität: Sterile filtered

Immunogen:

Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a peptide corresponding to an internal area of human PAI-2 protein.

Immunogen Type: Conjugated Peptide

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 10 μg/mL

Application Note: This affinity purified antibody has been tested for use in ELISA, Immunochemistry, and western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band 42-46.6 kDa in size corresponding to PAI-2 protein by western blotting in the appropriate cell lysate or extract.

Western Blot Dilution: 1:500 - 1:2,000

ELISA Dilution: 1:100,000 - 150,000

Other: User Optimized

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.2 mg/mL

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: None

Preservative: 0.01 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Haltbarkeit: 12 months

Referenzen für anti-SERPINB2 Antikörper (ABIN349627)

Godtfredsen, Sidelmann, Dolleris, Jørgensen, Johansen, Pedersen, Palarasah, Gram: "Fibrinolytic Changes in Women with Preeclampsia." in: Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis, Vol. 28, pp. 10760296221126172, (2022) (PubMed).

Details zu SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Andere Bezeichnung: SERPINB2

Substanzklasse: Amino Acid

Hintergrund: Background: Extracellular plasminogen activator inhibitor type-2 (also known as PAI-2, Placental plasminogen activator inhibitor, Monocyte Arg-serpin, Urokinase inhibitor, SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2) is a coagulation factor and a potent inhibitor of urokinase-type plasminogen activator (u-PA) and also acts as a multifunctional protein. It is present in most cells, especially monocytes and macrophages. PAI-2 exists in two forms, a 60- kDa, secreted, extracellular, glycosylated form and a 43- kDa intracellular form. It is a multifunctional protein that plays a role in cell differentiation, in prevention of programmed cell death, in the regulation of cell proliferation, in the inhibition of microbial proteinases and in the protection against stromal degradation. High levels of the PAI-2 protein are associated with a good prognosis in breast cancer, small cell lung, ovarian cancer, and inhibition of metastasis. PAI-2 also plays a role in inflammation on the surface of the eye. PAI-2 may cooperate with pRb2/p130 in modulating PAI-2 gene expression by chromatin remodeling.

Gen-ID: 5055, 4505595

UniProt: P05120

Pathways: Autophagie