ORAI3 Antikörper (N-Term)
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- Target Alle ORAI3 Antikörper anzeigen
- ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
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Bindungsspezifität
- N-Term
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Reaktivität
- Human, Ratte, Maus
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser ORAI3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Marke
- IHC-plus™
- Spezifität
- Recognizes human ORAI3, also known as Transmembrane protein 142C (TMEM142C), a 31.5 kD multi-pass membrane protein belonging to the ORAI family. Antigen stimulation of immune cells triggers Ca2+ entry through Ca2+ release-activated Ca2+ (CRAC) channels. CRAC channels are the main pathway for Ca2+ influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT. ORAI3 is one of two mammalian homologs of ORAI1, a four- transmembrane spanning protein that is an essential component of CRAC channels. ORAI3, along with ORAI1 and ORAI2, functions as a Ca2+ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca2+ sensor. Studies indicate that ORAI3 channels undergo a lesser degree of depotentiation than ORAI1 or ORAI2. AHP1496 is not expected to cross react with either ORAI1 or ORAI2.
- Aufreinigung
- Affinity purified
- Immunogen
- A 15 amino acid peptide from near the amino terminus of human ORAI3.
- Top Product
- Discover our top product ORAI3 Primärantikörper
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- Applikationshinweise
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Approved: IHC, IHC-P (5 μg/mL), WB
Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 5 μg/mL. Western Blot: LS-B2385 detects a band of approximately 35kD in A20 cell lysates. - Kommentare
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Target Species of Antibody: Human
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- Lot specific
- Buffer
- PBS, 0.02 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing. Store undiluted.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- 4°C or -20°C, Avoid freeze-thaw cycles. Store undiluted.
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- Target
- ORAI3 (ORAI Calcium Release-Activated Calcium Modulator 3 (ORAI3))
- Andere Bezeichnung
- ORAI3 (ORAI3 Produkte)
- Synonyme
- ORAI3 antikoerper, TMEM142C antikoerper, 9930124N15 antikoerper, BC061259 antikoerper, Tmem142c antikoerper, RGD1306538 antikoerper, ORAI calcium release-activated calcium modulator 3 antikoerper, ORAI3 antikoerper, Orai3 antikoerper
- Hintergrund
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Name/Gene ID: ORAI3
Synonyms: ORAI3, Protein orai-3, TMEM142C, Transmembrane protein 142C - Gen-ID
- 93129
- UniProt
- Q9BRQ5
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