KDM5A Antikörper (AA 1416-1434)
Kurzübersicht für KDM5A Antikörper (AA 1416-1434) (ABIN3201015)
Target
Alle KDM5A Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Bindungsspezifität
- AA 1416-1434
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Spezifität
- Specific to human and mouse RBP2. Can detect endogenous levels of RBP2.
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Aufreinigung
- Purified
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Sterilität
- Sterile filtered
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Immunogen
- A synthetic peptide corresponding to human RBP2, aa 1416-1434.
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Isotyp
- IgG2a kappa
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Applikationshinweise
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1. Western blotting: ~1 g/mL
2. Immunofluorescence staining
3. Flow Cytometry: 1 g for 10^6 cells -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- PBS, 50 % glycerol
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Konservierungsmittel
- Azide free
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Lagerung
- -20 °C
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: "Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation." in: Molecular cell, Vol. 31, Issue 4, pp. 520-30, (2008) (PubMed).
: "RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3." in: Cell, Vol. 128, Issue 6, pp. 1063-76, (2007) (PubMed).
: "The retinoblastoma binding protein RBP2 is an H3K4 demethylase." in: Cell, Vol. 128, Issue 5, pp. 889-900, (2007) (PubMed).
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- KDM5A (Lysine (K)-Specific Demethylase 5A (KDM5A))
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Andere Bezeichnung
- KDM5A
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Hintergrund
- RBP2 was originally identified as a retinoblastoma binding protein. It is also known as JARID1A (Jumonji, AT rich interactive domain 1A). RBP2 plays both negative and positive roles in RB- mediated transcriptional activation, depending on the kinds of genes and regulates differentiation by its function as an H3K4 histone demethylase.
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UniProt
- P29375
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Pathways
- Chromatin Binding, Warburg Effekt
Target
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