STXBP1 Antikörper (pSer515)

Produktnummer ABIN318802

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch STXBP1 in WB. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte, Rind (Kuh), Affe, Hund, Huhn und Xenopus laevis.

Kurzübersicht für STXBP1 Antikörper (pSer515) (ABIN318802)

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Affe, Hund, Huhn, Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser STXBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-STXBP1 Antikörper

Bindungsspezifität: pSer515

Spezifität: This antibody recognises Munc-18 phosphorylated at serine 515.

Aufreinigung: Purified

Immunogen: Phosphopeptide corresponding to amino acid sequence surrounding phosphorylated Ser515 of Munc-18.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 1: 1000, detects a band/s of approximately 65 kDa in rat cortex cell lysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 10 mM Hepes pH 7.5 containing 0.09 % Sodium Azide (NaN3), 50 % Glycerol and 0.01 % Bovine Serum Albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu STXBP1

Target: STXBP1 (Syntaxin Binding Protein 1 (STXBP1))

Andere Bezeichnung: STXBP1 / UNC18A

Hintergrund: Munc-18 is a 67 kDa member of the STXBP/UNC-18/SEC1 family. It is neural specific, expressed in the brain, spinal cord and at very high levels in axons. Munc-18 is crucial to calcium-dependent neurotransmitter release, facilitating synaptic vesicle docking and fusion. It inhibits the formation of soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor (SNARE) complex by binding syntaxin 1 preventing the other components (synaptobrevin and synaptosomal associated protein of 25 kDa (SNAP-25)) from binding. The function of Munc-18 is regulated by the phosphorylation of serine 515 by protein kinase C. Munc-18 is also involved in the onset of female puberty through its regulation of glutamate release.Synonyms: N-Sec1, Syntaxin-binding protein 1, Unc-18 homolog, Unc-18-1, Unc-18A

Gen-ID: 25558

NCBI Accession: NP_037170

UniProt: P61765

Pathways: Synaptic Vesicle Exocytosis, Dicarboxylic Acid Transport