UNG Antikörper (N-Term)

Produktnummer ABIN318787

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch UNG in WB. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Ratte.

Kurzübersicht für UNG Antikörper (N-Term) (ABIN318787)

Target: UNG (Uracil-DNA Glycosylase (UNG))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-UNG Antikörper

Bindungsspezifität: N-Term

Spezifität: This antibody recognises uracil-DNA glycosylase 1 (UNG1), a member of the uracil-DNA glycosylase and cyclin family.

Aufreinigung: Purified

Immunogen: 14 amino acid peptide sequence near the amino terminus of human UNG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 34.6 kDa in C2C/2 celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Hintergrund: Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination. UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.Synonyms: DGU, UDG, UNG1, UNG15

Gen-ID: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response