UNG Antikörper (N-Term)

Produktnummer ABIN318787

Produktdetails anti-UNG Antikörper

Target: UNG (Uracil-DNA Glycosylase (UNG))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser UNG Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody recognises uracil-DNA glycosylase 1 (UNG1), a member of the uracil-DNA glycosylase and cyclin family.

Aufreinigung: Purified

Immunogen: 14 amino acid peptide sequence near the amino terminus of human UNG1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western Blot: 0.5 - 1.0g/mL, detects a band of approximately 34.6 kDa in C2C/2 celllysates.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for up to one month or (in aliquots) at -20 °C for longer.

Details zu UNG

Target: UNG (Uracil-DNA Glycosylase (UNG))

Abstract: UNG Produkte

Synonyme: DGU antikoerper, HIGM4 antikoerper, HIGM5 antikoerper, UDG antikoerper, UNG1 antikoerper, UNG15 antikoerper, UNG2 antikoerper, ung antikoerper, zgc:56102 antikoerper, PSPTO4236 antikoerper, BA5648 antikoerper, ECK2578 antikoerper, JW2564 antikoerper, An02g14790 antikoerper, AO090001000732 antikoerper, DDBDRAFT_0204444 antikoerper, DDBDRAFT_0214910 antikoerper, DDB_0204444 antikoerper, DDB_0214910 antikoerper, uracil-DNA glycosylase antikoerper, uracil DNA glycosylase antikoerper, uracil DNA glycosylase a antikoerper, uracil-DNA glycosylase Ung antikoerper, uracil-DNA-glycosylase antikoerper, uracil DNA glycosylase L homeolog antikoerper, uracil glycosylase antikoerper, temporal expression: early antikoerper, ung antikoerper, ung2 antikoerper, Ung antikoerper, UNG antikoerper, unga antikoerper, STY2840 antikoerper, ung.L antikoerper, ANI_1_3358024 antikoerper, AOR_1_1318164 antikoerper, uglA antikoerper, Arnit_2731 antikoerper, D4R antikoerper

Substanzklasse: Viral Protein

Hintergrund: Two isoforms of UNG exist, isoform 1 is expressed in the mitochondria of in skeletal muscle, heart and testicles while isoform 2 (UNG2) is more abundant in proliferating tissues and expressed in the nucleus. Uracil residues can be misincorporated into DNA by DNA polymerase or by deamination of cytosine. UNG1 is a major enzyme in base excision repair, excising the misincorporated uracil residues in a process crucial to increasing immunoglobulin diversity. In association with activation-induced cytosine deaminase, UNG is also essential to the generation of strand breaks that initiate class switch recombination. UNG is also involved in the innate immune response against retroviral infections, HIV-1 accessory protein Vpr induces the rapid degradation of UNG2.Synonyms: DGU, UDG, UNG1, UNG15

Gen-ID: 7374

NCBI Accession: NP_003353

UniProt: P13051

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response