Collagen Type I Antikörper

Produktnummer ABIN318518

Der Kaninchen Polyklonal Anti-Collagen Type I-Antikörper wurde für IHC (fro), IF und EIA validiert. Er ist geeignet, Collagen Type I in Proben von Human und Schwein zu detektieren.

Kurzübersicht für Collagen Type I Antikörper (ABIN318518)

Target: Collagen Type I (COL1) (Collagen, Type I (COL1))

Reaktivität: Human, Schwein

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Collagen Type I Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Produktdetails anti-Collagen Type I Antikörper

Spezifität: This antibody reacts with native and heat denatured Porcine Collagen type 1 and 3. Less than 0.5 % reactivity is observed with Porcine Albumin and Immunoglobulins.

Kreuzreaktivität (Details): Also reacts to: type III

Aufreinigung: Purified

Immunogen: Porcine Collagen, types 1 and 3 from skin

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunofluorescence: 1/10-1/40. ELISA: 1/500-1/2000. Immunohistochemistry on Frozen Sections: 1/10-1/40.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Rekonstitution: Restore the vial (50 μg) with 500 μL of sterile distilled water or saline.

Buffer: Mannitol, dextran and salts.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Prior to reconstitution store at 2-8 °C. Following reconstitution store (in aliquots) at -20 °C.

Details zu Collagen Type I

Target: Collagen Type I (COL1) (Collagen, Type I (COL1))

Andere Bezeichnung: Collagen Type I

Hintergrund: Collagen I is a fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. Collagen III is a fibrillar collagen that is found in extensible connective tissues such as skin, lung, and the vascular system, frequently in association with Collagen I. Mutations in this gene are associated with Ehlers Danlos syndrome type IV, and with aortic and arterial aneurysms. Although alternate transcripts have been detected for this gene, they are the result of mutations, these mutations alter splicing, often leading to the exclusion of multiple exons.Synonyms: Alpha-1 type I collagen, Alpha-2 type I collagen, COL1A1, COL1A2

Gen-ID: 1277

NCBI Accession: NP_000079

UniProt: P02452