PAK4 Antikörper
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- Target Alle PAK4 Antikörper anzeigen
- PAK4 (P21-Activated Kinase 4 (PAK4))
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser PAK4 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- PAK4/5/6 antibody detects endogenous levels of PAK4/5/6 protein.(region surrounding Val469)
- Kreuzreaktivität (Details)
- Species reactivity (tested):Human, Mouse and Rat.
- Aufreinigung
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product PAK4 Primärantikörper
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- Applikationshinweise
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ELISA: 1/5000approx. 1/10000. Western Blot: 1/500approx. 1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS) with 0.05 % Sodium Azide as preservative, approx. pH 7.2.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- PAK4 (P21-Activated Kinase 4 (PAK4))
- Andere Bezeichnung
- PAK4 (PAK4 Produkte)
- Synonyme
- 5730488L07Rik antikoerper, AW555722 antikoerper, mKIAA1142 antikoerper, im:5916170 antikoerper, wu:fd12b01 antikoerper, zgc:92014 antikoerper, p21 (RAC1) activated kinase 4 antikoerper, p21 protein (Cdc42/Rac)-activated kinase 4 antikoerper, PAK4 antikoerper, Pak4 antikoerper, pak4 antikoerper
- Hintergrund
- Three recently identified isoforms of serine/threonine kinases, designated alphaPAK p68, betaPAK p65 and gammaPAK p62, have been shown to exhibit a high degree of sequence homology with the S. cerevisiaekinase STE20, involved in pheromone signaling. The alpha, beta and gammaPAK isoforms complex specifically with Rac1 and Cdc42 in their active GTP bound state, inhibiting their intrinsic GTPase activity leading to their autophosphorylation. Once phosphorylated and their affinity for Rac/Cdc42 reduced, the PAK isoforms disassociate from the complex to seek downstream substrates. One such putative substrate is MEK kinase, an upstream effector of MEK4 which is involved in the JNK signaling pathway. While the PAK isoforms interact in a GTP-dependent manner with Rac1 and Cdc42, they do not interact with Rho.Synonyms: KIAA1142, KIAA1264, PAK 4, PAK-4, PAK-5, PAK-5, PAK-6, PAK-7, PAK5, Serine/threonine-protein kinase PAK 4, Serine/threonine-protein kinase PAK 6, Serine/threonine-protein kinase PAK 7, p21-activated kinase 4, p21-activated kinase 5, p21-activated kinase 6, p21-activated kinase 7
- Molekulargewicht
- approx. 80 kDa
- Gen-ID
- 10298
- NCBI Accession
- NP_001014831
- UniProt
- O96013
- Pathways
- RTK Signalweg
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