LPAR1 Antikörper
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- Target Alle LPAR1 Antikörper anzeigen
- LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
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Reaktivität
- Human, Ratte
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LPAR1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- Spezifität
- This antibody detects endogenous levels of EDG-2 protein.(region surrounding Trp45)
- Aufreinigung
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product LPAR1 Primärantikörper
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- Applikationshinweise
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Western Blot: 1/500-1/1000. Immunohistochemistry: 1/50-1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 1.0 mg/mL
- Buffer
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- LPAR1 (Lysophosphatidic Acid Receptor 1 (LPAR1))
- Andere Bezeichnung
- EDG-2 / LPAR1 (LPAR1 Produkte)
- Synonyme
- EDG2 antikoerper, GPR26 antikoerper, Gpcr26 antikoerper, LPA1 antikoerper, Mrec1.3 antikoerper, VZG1 antikoerper, edg-2 antikoerper, rec.1.3 antikoerper, vzg-1 antikoerper, Edg2 antikoerper, EDG-2 antikoerper, 5031439C20 antikoerper, AI326300 antikoerper, Kdt2 antikoerper, lpA1 antikoerper, edg2 antikoerper, si:dz22b13.1 antikoerper, si:dz46m7.1 antikoerper, zgc:92157 antikoerper, LPA receptor 1-A antikoerper, LPA-1-A antikoerper, gpr26 antikoerper, lpa1 antikoerper, lpa1r antikoerper, lpa1r1 antikoerper, lpar1 antikoerper, lpar1-a antikoerper, lpar1-b antikoerper, vzg1 antikoerper, xLPA1-1 antikoerper, LPA receptor 1-B antikoerper, LPA-1-B antikoerper, edg2-A antikoerper, xLPA1-2 antikoerper, xlpa1R antikoerper, lysophosphatidic acid receptor 1 antikoerper, lysophosphatidic acid receptor 1 S homeolog antikoerper, lysophosphatidic acid receptor 1 L homeolog antikoerper, LPAR1 antikoerper, Lpar1 antikoerper, lpar1 antikoerper, lpar1.S antikoerper, lpar1.L antikoerper
- Hintergrund
- The EDG (endothelial differentiation gene) family of G protein-coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high affinity. EDG-6 is a low affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG-4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.Synonyms: EDG2, LPA receptor 1, LPA-1, LPA1, LPAR1, Lysophosphatidic acid receptor 1, Lysophosphatidic acid receptor Edg-2
- Molekulargewicht
- approx. 38 kDa
- Gen-ID
- 1902
- NCBI Accession
- NP_001392
- UniProt
- Q92633
- Pathways
- Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
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