G Protein-Coupled Receptor 119 Antikörper

Produktnummer ABIN317642

Der Kaninchen Polyklonal anti-G Protein-Coupled Receptor 119 Antikörper wird verwendet zum Nachweis von G Protein-Coupled Receptor 119 in Proben von Human. Er wurde validiert für WB und IF.

Kurzübersicht für G Protein-Coupled Receptor 119 Antikörper (ABIN317642)

Target: G Protein-Coupled Receptor 119 (GPR119)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser G Protein-Coupled Receptor 119 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Produktdetails anti-G Protein-Coupled Receptor 119 Antikörper

Spezifität: This antibody detects endogenous levels of GPR119 protein.(region surrounding Val227)

Aufreinigung: Affinity Chromatography using epitope-specific immunogen.

Anwendungsinformationen

Applikationshinweise: ELISA: 1/1000-1/5000. Western Blot: 1/500-1/1000.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.2 containing 0,05 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu G Protein-Coupled Receptor 119

Target: G Protein-Coupled Receptor 119 (GPR119)

Andere Bezeichnung: GPR119

Hintergrund: G protein-coupled receptors (GPRs) are a protein family of transmembrane receptors that transmit an extracellular signal (ligand binding) into an intra cellular signal (G protein activation). GPR signaling is an evolutionarily ancient mechanism used by all eukaryotes to sense environmental stimuli and mediate cell-cell communication. All of the receptors have seven membrane- spanning domains and the extracellular parts of the receptor can be glycosylated. These extracellular loops also contain two highly conserved cysteine residues which create disulfide bonds to stabilize the receptor structure. GPR119 is a 335 amino acid protein that is mainly expressed in the pancreas. It is an endogenous receptor for lysophosphatidylcholine (LPC), which is is a lipid mediator involved in insulin secretion from pancreatic cells. GPR119 may participate in this insulin secretion, suggesting that it may be potential target for new anti-diabetic drugs.Synonyms: G-protein coupled receptor 119, Glucose-dependent insulinotropic receptor

Molekulargewicht: approx. 37 kDa

Gen-ID: 139760

NCBI Accession: NP_848566

UniProt: Q8TDV5

Pathways: Hormone Transport, Peptide Hormone Metabolism