IL12B Antikörper

Produktnummer ABIN317391

Dieses Anti-IL12B-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von IL12B in FACS, EIA und Func. Geeignet für Human, Schaf und Rind (Kuh).

Kurzübersicht für IL12B Antikörper (ABIN317391)

Target: IL12B (Interleukin 12 beta (IL12B))

Reaktivität: Human, Schaf, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL12B Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: CC326

Produktdetails anti-IL12B Antikörper

Spezifität: This antibody recognizes Interleukin-12. It has been shown to block the biological activity of IL-12.

Produktmerkmale: Synonyms: Interleukin-12B, IL-12B, IL-12 subunit p40, CLMF p40, NKSF2, Cytotoxic lymphocytematuration factor 40 kDa subunit, NK cell stimulatory factor chain 2

Aufreinigung: Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

Immunogen: Recombinant bovine IL-12

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA: 1/100 - 1/1000. Flow cytometry: 1/1000, use 10 μL to label 10^6 cells of 100 l. Functional assays: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, None, None

Konservierungsmittel: Azide free

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C. Avoid repeated freezing and thawing.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu IL12B

Target: IL12B (Interleukin 12 beta (IL12B))

Andere Bezeichnung: Interleukin-12 beta / IL12B

Hintergrund: Interleukin 12 (IL12) can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine activated killer cells, and stimulate the production of IFN gamma by resting PBMC. IL12 induces IFN gamma, TNF alpha production in T and NK cells, costimulation of PBL proliferation, proliferation/differentiation of TH1 T lymphocytes. It is downregulated by IL10, homodimeric p40 antagonistic to functional p70 heterodimer. IL12R beta 1 binds p40 but when dimeric with IL12R beta 2 binds p35.Synonyms: CLMF p40, Cytotoxic lymphocyte maturation factor 40 kDa subunit, IL-12 subunit p40, IL-12B, Interleukin-12B, NK cell stimulatory factor chain 2, NKSF2

Gen-ID: 281857

UniProt: P46282

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation