POMC Antikörper (N-Term)

Produktnummer ABIN316639

Dieser Maus Monoklonal Antikörper detektiert spezifisch POMC in IHC (p) und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Ratte.

Kurzübersicht für POMC Antikörper (N-Term) (ABIN316639)

Target: POMC (Proopiomelanocortin (POMC))

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POMC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Klon: 57 (BGN-1388-66)

Produktdetails anti-POMC Antikörper

Bindungsspezifität: AA 1-24, N-Term

Spezifität: This ACTH antibody (Clone 57, BGN/1388/66) recognises 1-24 ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. It does not recognise 17-39 ACTH (CLIP). Cross-reacts with Rat N-terminal ACTH.

Produktmerkmale: Synonyms: Corticotropin, Adrenocorticotropic hormone, ACTH

Aufreinigung: Purified IgG prepared by affinity chromatography on Protein A

Immunogen: Synthetic peptide corresponding to the amino acids 1-24 of the Human ACTH conjugated toKeyhole Limpet Haemocyanin. AA Sequence: SYSMEHFRWGKPVGKKRRPVKVYP

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Immunohistochemistry on Formalin Fixed Paraffin Embedded Sections: 1/100-1/200(Requires protein digestion pre-treatment of paraffin sections e. g. trypsin or pronase).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.2, containing 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu POMC

Target: POMC (Proopiomelanocortin (POMC))

Andere Bezeichnung: POMC

Hintergrund: ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.Synonyms: Adrenocorticotropic hormone, Corticotropin, POMC

Gen-ID: 5443

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour