PUMA Antikörper

Produktnummer ABIN308637

Der Kaninchen Polyklonal anti-PUMA Antikörper (ABIN308637) detektiert spezifisch PUMA in WB. Dieser Antikörper reagiert spezifisch mit Proben aus Maus.

Kurzübersicht für PUMA Antikörper (ABIN308637)

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PUMA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PUMA Antikörper

Kreuzreaktivität: Human

Aufreinigung: affinity purified

Immunogen: Reacts with a 17 residue sequence [EQHLESPVPSAPGALAG] found in the exon-3-encoded region in the human PUMA-alpha and PUMA-beta forms of the protein. Recognizes both forms of the protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Lagerung: -20 °C

Details zu PUMA

Target: PUMA (BBC3) (BCL2 Binding Component 3 (BBC3))

Andere Bezeichnung: PUMA

Hintergrund: A novel gene PUMA (p53 upregulated modulator of apoptosis) is a target for activation by the p53 tumor-suppressor gene. p53 functions as a transcriptional activator, and influences p53-inducible genes that play a role in the induction of apoptosis in response to p53. Antisense inhibition of PUMA expression reduced the apoptotic response to p53, and PUMA is likely to play a role in mediating p53-induced cell death through the cytochrome c/Apaf-1-dependent pathway. In human and mouse, PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53.

Pathways: p53 Signalweg, Positive Regulation of Endopeptidase Activity