LEF1 Antikörper (all Isoforms)

Produktnummer ABIN306725

Der Maus Monoklonal anti-LEF1 Antikörper wird verwendet zum Nachweis von LEF1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für LEF1 Antikörper (all Isoforms) (ABIN306725)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LEF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1C3-1D10

Produktdetails anti-LEF1 Antikörper

Bindungsspezifität: all Isoforms

Verwendungszweck: Mouse anti Human LEF-1 all isoforms

Kreuzreaktivität: Human

Produktmerkmale: Lymphoid Enhancer Factor-1 (LEF-1) is an HMG 1/2-like DNA binding/bending protein and is a member of the LEF/TCF transcription factor family. There are four LEF/TCF family members in mammalian systems (LEF-1, TCF-1, TCF-3 and TCF-4), and orthologs to these factors have been identified in many different species. LEF/TCFs are downstream mediators of Wnt/Wingless signals. Wnt signaling drives cell polarity, cell fate and cell growth decisions in embryonic tissues and in post-natal tissues that continue to develop from mitotically active stem cell precursors. Misregulation of Wnt signaling is also implicated as a root cause of many different cancers, such as colon cancer, melanoma, breast cancer, prostate cancer and others. This antibody recognizes an epitope in amino acids 256-308 of LEF-1. This region is between the transactivation domain and the HMG binding domain of LEF-1 and is conserved in all LEF-1 isoforms.

Aufreinigung: Protein G Chromatography

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Antibody detects all LEF-1 isoforms by Western blot. Does not cross-react with TCF-1 or TCF-4. Optimal concentration should be evaluated by serial dilutions.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Andere Bezeichnung: LEF-1

Hintergrund: Anti-Lymphoid Enhancer Factor-1 (All Isoforms) Monoclonal Antibody

UniProt: Q9UJU2

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding