Cytochrome C Antikörper (full length)

Produktnummer ABIN306559

Dieser Schaf Polyklonal Antikörper detektiert spezifisch Cytochrome C in WB, IHC und IP. Es zeigt Reaktivität gegenüber Proben von Human, Ratte, Hund und Kaninchen.

Kurzübersicht für Cytochrome C Antikörper (full length) (ABIN306559)

Target: Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

Reaktivität: Human, Ratte, Hund, Kaninchen

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser Cytochrome C Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Produktdetails anti-Cytochrome C Antikörper

Bindungsspezifität: full length

Verwendungszweck: Sheep anti Human Cytochrome c

Kreuzreaktivität: Human

Produktmerkmale: Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. Defects in CYCS are the cause of thrombocytopenia type 4 (THC4) also known as autosomal dominant thrombocytopenia type 4. Thrombocytopenia is the presence of relatively few platelets in blood. THC4 is a non-syndromic form of thrombocytopenia. Clinical manifestations of thrombocytopenia are absent or mild. THC4 may be caused by dysregulated platelet formation.

Aufreinigung: Ammonium Sulfate Precipitation

Immunogen: Full length recombinant Cytochrome C

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Applications: Western Blot 1:5,000, shows a MW of 14.4 kDa. May be used in immunofluorescence applications with human and rat cells, Immunoprecipitation - Empirical.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: phosphate buffered saline with 0.08 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Product should be stored at -20°C. Aliquot to avoid freeze/thaw cycles

Details zu Cytochrome C

Target: Cytochrome C (CYCS) (Cytochrome C, Somatic (CYCS))

Andere Bezeichnung: Cytochrome c

Hintergrund: Sheep anti cytochrome c, cyto c, cytochrome-c

UniProt: P99999, P62898, P00008, P00011

Pathways: Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity