Cathepsin K Antikörper (AA 115-329)

Produktnummer ABIN3044511

Produktdetails anti-Cathepsin K Antikörper

Target: Cathepsin K (CTSK)

Bindungsspezifität: AA 115-329

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Cathepsin K Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Cathepsin K(CTSK) detection. Tested with WB, IHC-P in Human.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Cathepsin K(CTSK) detection. Tested with WB, IHC-P in Human.
Gene Name: cathepsin K
Protein Name: Cathepsin K

Aufreinigung: Immunogen affinity purified.

Immunogen: E. coli-derived human Cathepsin K recombinant protein (Position: A115-M329). Human Cathepsin K shares 86.9% and 88.8% amino acid (aa) sequence identity with mouse and rat Cathepsin K, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu Cathepsin K

Target: Cathepsin K (CTSK)

Andere Bezeichnung: CTSK (CTSK Produkte)

Synonyme: CTS02 antikoerper, CTSO antikoerper, CTSO1 antikoerper, CTSO2 antikoerper, PKND antikoerper, PYCD antikoerper, AI323530 antikoerper, MMS10-Q antikoerper, Ms10q antikoerper, catK antikoerper, CTSK antikoerper, wu:fa95f03 antikoerper, wu:fb08b05 antikoerper, zgc:110367 antikoerper, cts02 antikoerper, ctso antikoerper, ctso1 antikoerper, ctso2 antikoerper, pknd antikoerper, pycd antikoerper, OC-2 antikoerper, catk antikoerper, cathepsin K antikoerper, cathepsin K L homeolog antikoerper, Cathepsin K antikoerper, CTSK antikoerper, Ctsk antikoerper, ctsk antikoerper, ctsk.L antikoerper, catk antikoerper

Hintergrund: Cathepsin K, abbreviated CTSK, is an enzyme that in humans is encoded by the CTSK gene. It is mapped to 1q21. The protein encoded by this gene is a lysosomal cysteine protease involved in bone remodeling and resorption. And this protein, which is a member of the peptidase C1 protein family, is expressed predominantly in osteoclasts. Additionally, the enzyme's ability to catabolize elastin, collagen, and gelatin allow it to break down bone and cartilage. This catabolic activity is also partially responsible for the loss of lung elasticity and recoil inemphysema. Cathepsin K inhibitors, such as odanacatib, show great potential in the treatment of osteoporosis. Cathepsin K is degraded by Cathepsin S, called Controlled Cathepsin Cannibalism.

Synonyms: Cathepsin K antibody|Cathepsin O antibody|Cathepsin O1 antibody|Cathepsin O2 antibody|Cathepsin X antibody|CATK_HUMAN antibody|CTS02 antibody|Ctsk antibody|CTSO antibody|CTSO1 antibody|CTSO2 antibody|MGC23107 antibody|PKND antibody|PYCD antibody

Gen-ID: 1513

UniProt: P43235

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades