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Ceruloplasmin Antikörper (AA 20-258)

CP Reaktivität: Ratte, Maus WB, IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3044508
  • Target Alle Ceruloplasmin (CP) Antikörper anzeigen
    Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))
    Bindungsspezifität
    • 6
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 20-258
    Reaktivität
    • 52
    • 10
    • 5
    Ratte, Maus
    Wirt
    • 43
    • 8
    • 6
    • 3
    • 1
    Kaninchen
    Klonalität
    • 51
    • 8
    Polyklonal
    Konjugat
    • 34
    • 10
    • 7
    • 4
    • 2
    • 2
    • 2
    Dieser Ceruloplasmin Antikörper ist unkonjugiert
    Applikation
    • 38
    • 31
    • 25
    • 13
    • 12
    • 11
    • 7
    • 7
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-Ceruloplasmin/CP Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins.
    Produktmerkmale
    Rabbit IgG polyclonal antibody for Ceruloplasmin(CP) detection. Tested with WB, IHC-P in Mouse,Rat.
    Gene Name: ceruloplasmin (ferroxidase)
    Protein Name: Ceruloplasmin
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E. coli-derived mouse Ceruloplasmin recombinant protein (Position: R20-M258). Mouse Ceruloplasmin shares 80.8% and 91.2% amino acid (aa) sequence identity with human and rat Ceruloplasmin, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product CP Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat
    1. Koschinsky ML, Funk WD, van Oost BA, MacGillivray RT (Jul 1986)."Complete cDNA sequence of human preceruloplasmin". Proceedings of the National Academy of Sciences of the United States of America 83 (14): 5086-90. 2. Royle NJ, Irwin DM, Koschinsky ML, MacGillivray RT, Hamerton JL (May 1987). "Human genes encoding prothrombin and ceruloplasmin map to 11p11-q12 and 3q21-24, respectively". Somatic Cell and Molecular Genetics 13(3): 285-92. 3. Takahashi N, Ortel TL, Putnam FW (Jan 1984). "Single-chain structure of human ceruloplasmin: the complete amino acid sequence of the whole molecule". Proceedings of the National Academy of Sciences of the United States of America 81 (2): 390-4.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target
    Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))
    Andere Bezeichnung
    Cp (CP Produkte)
    Hintergrund

    Synonyms: Ceruloplasmin;1.16.3.1;Ferroxidase;Cp;

    Tissue Specificity: Expressed in many tissues, including liver, eye and brain. .

    Background: Ceruloplasmin  (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. It is mapped to 3q23-q25. The protein encoded by this gene is a metalloprotein that binds most of the copper in plasma and is involved in the peroxidation of Fe (II)transferrin to Fe (III) transferrin. Mutations in this gene cause aceruloplasminemia, which results in iron accumulation and tissue damage, and is associated with diabetes and neurologic abnormalities. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene.

    Molekulargewicht
    130 kDa
    Gen-ID
    12870
    UniProt
    Q61147
    Pathways
    Transition Metal Ion Homeostasis
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