Pleiotrophin Antikörper (C-Term)

Produktnummer ABIN3044398

Dieser Kaninchen Polyklonal Antikörper erkennt spezifisch Pleiotrophin in WB und IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 1 Publikation erwähnt.

Kurzübersicht für Pleiotrophin Antikörper (C-Term) (ABIN3044398)

Target: Pleiotrophin (PTN)

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Pleiotrophin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Pleiotrophin Antikörper

Bindungsspezifität: AA 150-168, C-Term

Verwendungszweck: Anti-Pleiotrophin/PTN Antibody

Sequenz: QAESKKKKKE GKKQEKMLD

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Pleiotrophin/PTN Antibody (ABIN3044398). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human Pleiotrophin, identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Pleiotrophin Antikörper (ABIN3044398)

Zhang, Liu, Liu, Zhou, Song, Cao, An: "miR-182 aids in receptive endometrium development in dairy goats by down-regulating PTN expression." in: PLoS ONE, Vol. 12, Issue 7, pp. e0179783, (2017) (PubMed).

Details zu Pleiotrophin

Target: Pleiotrophin (PTN)

Andere Bezeichnung: PTN

Hintergrund:

Synonyms: Pleiotrophin,PTN,Heparin-binding brain mitogen,HBBM,Heparin-binding growth factor 8,HBGF-8,Heparin-binding growth-associated molecule,HB-GAM,Heparin-binding neurite outgrowth-promoting factor 1,HBNF-1,Osteoblast-specific factor 1,OSF-1,PTN,HBNF1, NEGF1,

Tissue Specificity: Osteoblast and brain.

Background: Pleiotrophin (PTN) also known as heparin-binding brain mitogen (HBBM) or heparin-binding growth factor 8 (HBGF-8) or neurite growth-promoting factor 1 (NEGF1) or heparin affinity regulatory peptide (HARP) or heparin binding growth associated molecule (HB-GAM) is a protein that in humans is encoded by the PTN gene. PTN is the first member of a family of developmentally regulated cytokines. The PTN gene is mapped to 7q33-q34. A mutant PTN that contained only the first N-terminal 40 amino acids was a dominant negative. Pleiotrophin is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. Pleiotrophin binds to cell-surface nucleolin as a low affinity receptor. This binding can inhibit HIV infection.

Sequence Similarities: Belongs to the pleiotrophin family.

Molekulargewicht: 19 kDa

UniProt: P21246

Pathways: RTK Signalweg