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Integrin alpha 1 Antikörper (C-Term)

Dieses Anti-Integrin alpha 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Integrin alpha 1 in WB und IHC. Geeignet für Human, Maus und Ratte. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN3044325

Kurzübersicht für Integrin alpha 1 Antikörper (C-Term) (ABIN3044325)

Target

Alle Integrin alpha 1 (ITGA1) Antikörper anzeigen
Integrin alpha 1 (ITGA1)

Reaktivität

  • 73
  • 28
  • 17
  • 4
  • 3
Human, Maus, Ratte

Wirt

  • 61
  • 21
  • 4
  • 1
  • 1
Kaninchen

Klonalität

  • 66
  • 22
Polyklonal

Konjugat

  • 45
  • 6
  • 5
  • 4
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Integrin alpha 1 Antikörper ist unkonjugiert

Applikation

  • 59
  • 28
  • 26
  • 24
  • 23
  • 14
  • 13
  • 13
  • 6
  • 5
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 16
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1121-1134, C-Term

    Verwendungszweck

    Anti-Integrin alpha 1/ITGA1 Antibody Picoband®

    Sequenz

    SNQKRELAIQ ISKD

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Integrin alpha 1/ITGA1 Antibody (ABIN3044325). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human Integrin alpha 1, different from the related mouse and rat sequences by one amino acid.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Human, Rat, Mouse
    1. Douville, P., Seldin, M. F., Carbonetto, S. : Genetic mapping of the integrin alpha-1 gene (Vla1) to mouse chromosome 13. Genomics 14: 503-505, 1992. 2. Lee HJ, Kim SY, Koh JM, Bok J, Kim KJ, Kim KS, Park MH, Shin HD, Park BL, Kim TH, Hong JM, Park EK, Kim DJ, Oh B, Kimm K, Kim GS, Lee JY. Polymorphisms and haplotypes of integrinalpha1 (ITGA1) are associated with bone mineral absorbance and fracture risk in postmenopausal Koreans.Bone. 2007 Dec,41(6):979-86. Epub 2007 Sep 5. 3. Ekholm, E., Hankenson, K. D., Uusitalo, H., Hiltunen, A., Gardner, H., Heino, J., Penttinen, R. : Diminished callus size and cartilage synthesis in alpha-1 beta-1 integrin-deficient mice during bone fracture healing. Am. J. Path. 160: 1779-1785, 2002.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Zhang, Ren, Luo, Fan, Liu, Liang, Ma, Yu, Bai: "A small physiological electric field mediated responses of extravillous trophoblasts derived from HTR8/SVneo cells: involvement of activation of focal adhesion kinase signaling." in: PLoS ONE, Vol. 9, Issue 3, pp. e92252, (2014) (PubMed).

  • Target

    Integrin alpha 1 (ITGA1)

    Andere Bezeichnung

    ITGA1

    Hintergrund

    Synonyms: Integrin alpha-1,CD49 antigen-like family member A,Laminin and collagen receptor,VLA-1,CD49a,ITGA1,

    Tissue Specificity: Isoform 3 is expressed in pancreatic islets, testis, adrenal cortex, and perhaps other endocrine tissues, but not in brain. .

    Background: Integrin alpha 1 (ITGA1) chain associates with the beta 1 (ITGB1) chain to form a heterodimer that functions as a dual laminin/collagen receptor in neural cells and hematopoietic cells. ITGA1 has a 206-amino acid I domain in its N-terminal half, followed by 3 divalent cation-binding sites and a C-terminal transmembrane domain with a short cytoplasmic tail. It also has 28 potential N-glycosylation sites. Human ITGA1 was expressed in a mouse fibroblast cell line as a 180-kD protein. ITGA1 is involved in the early remodeling of osteoarthritic cartilage and plays an essential role in the regulation of mesenchymal stem cell proliferation and cartilage production. It also plays an essential role in the regulation of MSC proliferation and cartilage production.

    Sequence Similarities: Belongs to the integrin alpha chain family.

    Molekulargewicht

    190-200 kDa

    UniProt

    P56199

    Pathways

    EGFR Signaling Pathway, CXCR4-mediated Signaling Events, Signaling of Hepatocyte Growth Factor Receptor, Integrin Complex
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