YBX1 Antikörper (Middle Region)

Produktnummer ABIN3044148

Produktdetails anti-YBX1 Antikörper

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Bindungsspezifität: AA 137-152, Middle Region

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Nuclease-sensitive element-binding protein 1(YBX1) detection. Tested with WB in Human,Mouse,Rat.

Sequenz: KYAADRNHYR RYPRRR

Kreuzreaktivität (Details): Predicted Cross Reactivity: mouse, Rat
No cross reactivity with other proteins.
Predicted Cross Reactivity: Species predicted to be fit for the product based on sequence similarities.

Produktmerkmale: Rabbit IgG polyclonal antibody for Nuclease-sensitive element-binding protein 1(YBX1) detection. Tested with WB in Human,Mouse,Rat.
Gene Name: Y box binding protein 1
Protein Name: Nuclease-sensitive element-binding protein 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human YB1(137-152aa KYAADRNHYRRYPRRR), identical to the related rat and mouse sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Predicted Species: Mouse, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Details zu YBX1

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Andere Bezeichnung: YBX1 (YBX1 Produkte)

Synonyme: BP-8 antikoerper, CSDA2 antikoerper, CSDB antikoerper, DBPB antikoerper, MDR-NF1 antikoerper, NSEP-1 antikoerper, NSEP1 antikoerper, YB-1 antikoerper, YB1 antikoerper, Byb1 antikoerper, Cbfa antikoerper, Dbpb antikoerper, Ef1a antikoerper, Msy1 antikoerper, Nsep1 antikoerper, Yb1 antikoerper, bp-8 antikoerper, csda2 antikoerper, csdb antikoerper, dbpb antikoerper, frgy1 antikoerper, mdr-nf1 antikoerper, nsep-1 antikoerper, nsep1 antikoerper, yb1 antikoerper, 1700102N10Rik antikoerper, C79409 antikoerper, EF1A antikoerper, MSY1 antikoerper, dbpB antikoerper, mYB-1a antikoerper, nuclease sensitive element binding protein 1 antikoerper, Y-box binding protein 1 antikoerper, Y box binding protein 1 antikoerper, Y-box binding protein 1 S homeolog antikoerper, nuclease-sensitive element-binding protein 1 antikoerper, Y box protein 1 antikoerper, nsep1 antikoerper, YBX1 antikoerper, Ybx1 antikoerper, ybx1.S antikoerper, LOC479011 antikoerper

Hintergrund: YBX1(Y box binding protein 1), commonly referred to as "YB-1" by researchers, is a human protein. YB1 binding has an absolute requirement for the CCAAT box and relative specificity for the Y box. It has a molecular mass of 35,414 and contains 18 % basic residues and putative nuclear localization signals. The YBX1 gene is mapped on 1p34.2. Ybx1 was highly expressed in mouse erythroid myeloid lymphoid clone-1(EML), a hematopoietic precursor cell line, but that it was downregulated in myeloid progenitors and in Gmcsf-treated EML cells during myeloid differentiation. Ybx1 was expressed at high levels in myeloid leukemic cells at different developmental stages. Knockdown of YBX1 in a human leukemic cell line inhibited proliferation ability, induced apoptosis, and induced megakaryocytic differentiation in response to arsenic trioxide treatment. YBX1 is downregulated during myeloid differentiation and aberrant YBX1 expression in leukemic cells may contribute to leukemia development by blocking differentiation.

Synonyms: BP 8 antibody|CBF-A antibody|CCAAT binding transcription factor I subunit A antibody|CCAAT-binding transcription factor I subunit A antibody|CSDA2 antibody|CSDB antibody|DBPB antibody|DNA binding protein B antibody|DNA-binding protein B antibody|EFI-A antibody|Enhancer factor I subunit A antibody|MDR NF1 antibody|MGC104858 antibody|MGC110976 antibody|MGC117250 antibody|NSEP 1 antibody|NSEP1 antibody|Nuclease sensitive element binding protein 1 antibody|Nuclease-sensitive element-binding protein 1 antibody|p50 antibody|Q15905 antibody|Y-box binding protein 1 antibody|Y-box transcription factor antibody|Y-box-binding protein 1 antibody|YB 1 antibody|YB-1 antibody|YBOX1_HUMAN antibody|YBX 1 antibody|YBX1 antibody

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation