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POMC Antikörper (Middle Region)

Der Kaninchen Polyklonal Anti-POMC-Antikörper wurde für IHC validiert. Er ist geeignet, POMC in Proben von Human, Maus und Ratte zu detektieren. Es sind 2+ Publikationen verfügbar.
Produktnummer ABIN3043901

Kurzübersicht für POMC Antikörper (Middle Region) (ABIN3043901)

Target

Alle POMC Antikörper anzeigen
POMC (Proopiomelanocortin (POMC))

Reaktivität

  • 70
  • 42
  • 41
  • 6
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 64
  • 37
  • 1
Kaninchen

Klonalität

  • 63
  • 39
Polyklonal

Konjugat

  • 70
  • 6
  • 5
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser POMC Antikörper ist unkonjugiert

Applikation

  • 43
  • 39
  • 32
  • 29
  • 20
  • 18
  • 17
  • 13
  • 13
  • 13
  • 11
  • 8
  • 5
  • 5
  • 4
  • 3
  • 3
  • 2
  • 1
  • 1
Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 16
    • 10
    • 9
    • 6
    • 6
    • 5
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 138-176, Middle Region

    Verwendungszweck

    Anti-ACTH/POMC Antibody

    Sequenz

    SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-ACTH/POMC Antibody Picoband® (ABIN3043901). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence in the middle region of human ACTH, different from the related mouse and rat sequences by two amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat, Human
    1. Dibner, Charna, Schibler, Ueli, Albrecht, Urs (2010). "The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks". Annual Review of Physiology72: 517-549. 2. Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells". J. Biol. Chem. 265 (33): 20602-8. 3. Raikhinstein M, Zohar M, Hanukoglu I (February 1994). "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor". Biochim. Biophys. Acta 1220 (3): 329-32.

    Kommentare

    Antibody can be supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Huo, Liu, Wang, Zhang, Wang, Yang, Sun, Xu: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." in: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).

    Chen, Wang, Zhao, Zhang, Huang: "Effects of the extract of a Chinese herb Tripterygium wilfordii hook f on rat pituitary gland." in: The American journal of Chinese medicine, Vol. 33, Issue 6, pp. 945-55, (2006) (PubMed).

  • Target

    POMC (Proopiomelanocortin (POMC))

    Andere Bezeichnung

    POMC

    Hintergrund

    Synonyms: Pro-opiomelanocortin,POMC,Corticotropin-lipotropin,NPP,Melanotropin gamma,Gamma-MSH,Potential peptide,Corticotropin,Adrenocorticotropic hormone,ACTH,Melanotropin alpha,Alpha-MSH,Corticotropin-like intermediary peptide,CLIP,Lipotropin beta,Beta-LPH,Lipotropin gamma,Gamma-LPH,Melanotropin beta,Beta-MSH,Beta-endorphin,Met-enkephalin,POMC,

    Tissue Specificity: ACTH and MSH are produced by the pituitary gland.

    Background: Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

    Sequence Similarities: Belongs to the POMC family.

    Molekulargewicht

    30 kDa

    Gen-ID

    5443

    UniProt

    P01189

    Pathways

    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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