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POMC Antikörper (Middle Region)

POMC Reaktivität: Human, Maus, Ratte IHC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043901
  • Target Alle POMC Antikörper anzeigen
    POMC (Proopiomelanocortin (POMC))
    Bindungsspezifität
    • 16
    • 10
    • 9
    • 6
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 138-176, Middle Region
    Reaktivität
    • 64
    • 39
    • 37
    • 6
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 53
    • 35
    • 1
    Kaninchen
    Klonalität
    • 52
    • 37
    Polyklonal
    Konjugat
    • 59
    • 5
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser POMC Antikörper ist unkonjugiert
    Applikation
    • 32
    • 30
    • 29
    • 26
    • 19
    • 13
    • 13
    • 13
    • 11
    • 8
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Immunohistochemistry (IHC)
    Verwendungszweck
    Anti-ACTH/POMC Antibody
    Sequenz
    SYSMEHFRWG KPVGKKRRPV KVYPNGAEDE SAEAFPLEF
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-ACTH/POMC Antibody Picoband® (ABIN3043901). Tested in IHC applications. This antibody reacts with Human, Mouse, Rat.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence in the middle region of human ACTH, different from the related mouse and rat sequences by two amino acids.
    Isotyp
    IgG
    Top Product
    Discover our top product POMC Primärantikörper
  • Applikationshinweise
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse, Rat, Human
    1. Dibner, Charna, Schibler, Ueli, Albrecht, Urs (2010). "The Mammalian Circadian Timing System: Organization and Coordination of Central and Peripheral Clocks". Annual Review of Physiology72: 517-549. 2. Hanukoglu I, Feuchtwanger R, Hanukoglu A (November 1990). "Mechanism of corticotropin and cAMP induction of mitochondrial cytochrome P450 system enzymes in adrenal cortex cells". J. Biol. Chem. 265 (33): 20602-8. 3. Raikhinstein M, Zohar M, Hanukoglu I (February 1994). "cDNA cloning and sequence analysis of the bovine adrenocorticotropic hormone (ACTH) receptor". Biochim. Biophys. Acta 1220 (3): 329-32.
    Kommentare

    Antibody can be supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Huo, Liu, Wang, Zhang, Wang, Yang, Sun, Xu: "Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury." in: Neural regeneration research, Vol. 7, Issue 22, pp. 1729-35, (2015) (PubMed).

    Chen, Wang, Zhao, Zhang, Huang: "Effects of the extract of a Chinese herb Tripterygium wilfordii hook f on rat pituitary gland." in: The American journal of Chinese medicine, Vol. 33, Issue 6, pp. 945-55, (2006) (PubMed).

  • Target
    POMC (Proopiomelanocortin (POMC))
    Andere Bezeichnung
    POMC (POMC Produkte)
    Hintergrund

    Synonyms: Pro-opiomelanocortin,POMC,Corticotropin-lipotropin,NPP,Melanotropin gamma,Gamma-MSH,Potential peptide,Corticotropin,Adrenocorticotropic hormone,ACTH,Melanotropin alpha,Alpha-MSH,Corticotropin-like intermediary peptide,CLIP,Lipotropin beta,Beta-LPH,Lipotropin gamma,Gamma-LPH,Melanotropin beta,Beta-MSH,Beta-endorphin,Met-enkephalin,POMC,

    Tissue Specificity: ACTH and MSH are produced by the pituitary gland.

    Background: Adrenocorticotropic hormone (ACTH), also known as corticotropin, is a polypeptide tropic hormone produced and secreted by the anterior pituitary gland. It is an important component of the hypothalamic-pituitary-adrenal axis and is often produced in response to biological stress (along with its precursor corticotropin-releasing hormone from the hypothalamus). Its principal effects are increased production and release of corticosteroids. ACTH stimulates secretion of glucocorticoid steroid hormones from adrenal cortex cells, especially in the zona fasciculata of the adrenal glands. This gene can influence steroid hormone secretion by both rapid short-term mechanisms that take place within minutes and slower long-term actions. Besides, ACTH also enhances transcription of mitochondrial genes that encode for subunits of mitochondrial oxidative phosphorylation systems.

    Sequence Similarities: Belongs to the POMC family.

    Molekulargewicht
    30 kDa
    Gen-ID
    5443
    UniProt
    P01189
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour
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