ITPR3 Antikörper (N-Term)

Produktnummer ABIN3043863

Der Kaninchen Polyklonal anti-ITPR3 Antikörper (ABIN3043863) detektiert spezifisch ITPR3 in WB und IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für ITPR3 Antikörper (N-Term) (ABIN3043863)

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITPR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-ITPR3 Antikörper

Bindungsspezifität: AA 70-95, N-Term

Verwendungszweck: Anti-ITPR3 Antibody

Sequenz: QYWKAKQTKQ DKEKIADVVL LQKLQH

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-ITPR3 Antibody (ABIN3043863). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3, identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human, Mouse, Rat
Western blot, 0.1-0.5 μg/mL, Human

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Andere Bezeichnung: ITPR3

Hintergrund:

Synonyms: Inositol 1,4,5-trisphosphate receptor type 3,IP3 receptor isoform 3,IP3R 3,InsP3R3,Type 3 inositol 1,4,5-trisphosphate receptor,Type 3 InsP3 receptor,ITPR3,

Tissue Specificity: Expressed in intestinal crypt and villus epithelial cells.

Background: ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

Sequence Similarities: Belongs to the InsP3 receptor family.

Molekulargewicht: 270-300 kDa

Gen-ID: 3710

UniProt: Q14573

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling