ITPR3 Antikörper (N-Term)

Produktnummer ABIN3043863

Produktdetails anti-ITPR3 Antikörper

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Bindungsspezifität: AA 70-95, N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITPR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 3(ITPR3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: QYWKAKQTKQ DKEKIADVVL LQKLQH

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 3(ITPR3) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: inositol 1,4,5-trisphosphate receptor, type 3
Protein Name: Inositol 1,4,5-trisphosphate receptor type 3

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human ITPR3 (70-95aa QYWKAKQTKQDKEKIADVVLLQKLQH), identical to the related mouse and rat sequences.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, The detection limit for ITPR3 is approximately 0.1 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu ITPR3

Target: ITPR3 (Inositol 1,4,5-Trisphosphate Receptor, Type 3 (ITPR3))

Andere Bezeichnung: ITPR3 (ITPR3 Produkte)

Synonyme: Ip3r3 antikoerper, Itpr-3 antikoerper, IP3R antikoerper, IP3R3 antikoerper, IP3R3X antikoerper, inositol 1,4,5-triphosphate receptor 3 antikoerper, inositol 1,4,5-trisphosphate receptor type 3 antikoerper, inositol 1,4,5-trisphosphate receptor, type 3 antikoerper, Itpr3 antikoerper, ITPR3 antikoerper

Hintergrund: ITPR3 encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. ITP3 channels serve an important role in the taste transduction pathway of sweet, bitter and umami tastes the gustatory system. ITP3 channels allow the flow of Calcium out of the endoplasmic reticulum in response to IP3. Calcium cations result in the activation of TRPM5 which leads to a depolarisation generating potential and an action potential.

Synonyms: 4 antibody|5-trisphosphate receptor antibody|5-trisphosphate receptor type 3 antibody| FLJ36205 antibody|Inositol 1 antibody|Inositol 1,4,5 trisphosphate receptor type 3 antibody|InsP3R3 antibody|IP3 receptor antibody|IP3 receptor isoform 3 antibody|IP3R 3 antibody|IP3R antibody|IP3R3 antibody|ITPR 3 antibody|ITPR3 antibody|ITPR3_HUMAN antibody| Type 3 inositol 1 antibody|Type 3 inositol 1,4,5 trisphosphate receptor antibody|Type 3 InsP3 receptor antibody

Gen-ID: 3710

UniProt: Q14573

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, BCR Signaling