ITPR1 Antikörper (AA 2411-2758)

Produktnummer ABIN3043862

Produktdetails anti-ITPR1 Antikörper

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Bindungsspezifität: AA 2411-2758

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ITPR1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Inositol 1,4,5-trisphosphate receptor type 1(ITPR1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: inositol 1,4,5-trisphosphate receptor, type 1
Protein Name: Inositol 1,4,5-trisphosphate receptor type 1

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human IP3 receptor recombinant protein (Position: A2411-A2758). Human IP3 receptor shares 98% and 97% amino acid (aa) sequences identity with mouse and rat IP3 receptor, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, The detection limit for IP3 receptor is approximately 0.2 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Referenzen für anti-ITPR1 Antikörper (ABIN3043862)

Yu, Chen, Wang, Kuang, Liu, Zhang, Du: "Neuroprotective effect of kaempferol glycosides against brain injury and neuroinflammation by inhibiting the activation of NF-?B and STAT3 in transient focal stroke." in: PLoS ONE, Vol. 8, Issue 2, pp. e55839, (2013) (PubMed).

Details zu ITPR1

Target: ITPR1 (Inositol 1,4,5-Trisphosphate Receptor, Type 1 (ITPR1))

Andere Bezeichnung: ITPR1 (ITPR1 Produkte)

Synonyme: D6Pas2 antikoerper, ENSMUSG00000072853 antikoerper, Gm10429 antikoerper, IP3R1 antikoerper, InsP3R antikoerper, Ip3r antikoerper, Itpr-1 antikoerper, P400 antikoerper, Pcp-1 antikoerper, Pcp1 antikoerper, opt antikoerper, I145TR antikoerper, InsP3R1 antikoerper, INSP3R1 antikoerper, IP3R antikoerper, SCA15 antikoerper, SCA16 antikoerper, SCA29 antikoerper, inositol 1,4,5-trisphosphate receptor type 1 antikoerper, inositol 1,4,5-trisphosphate receptor 1 antikoerper, inositol 1,4,5-trisphosphate receptor, type 1 antikoerper, ITPR1 antikoerper, Itpr1 antikoerper

Hintergrund: Inositol 1,4,5-trisphosphate receptor type 1, also known as IP3R or IP3R1, is a protein that in humans is encoded by the ITPR1 gene. It is mapped to 3p26.1. The product of the ITPR1 gene is predominantly enriched in cerebellar Purkinje cells but is also concentrated in neurons in the hippocampal CA1 region, caudate-putamen, and cerebral cortex. The ITPR1 gene encodes the inositol 1,4,5-triphosphate(IP3) receptor, an intracellular IP3-gated calcium channel that modulates intracellular calcium signaling. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in ITPR1 cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders.

Synonyms: 4 antibody|5-trisphosphate receptor antibody|5-trisphosphate receptor type 1 antibody|DKFZp313E1334 antibody|DKFZp313N1434 antibody|inositol 1 4 5 triphosphate receptor type 1 antibody|Inositol 1 4 5 trisphosphate Receptor Type 1 antibody|Inositol 1 antibody|Inositol 145-trisphosphate Receptor Type 1 antibody|InsP3R1 antibody|IP3 antibody|IP3 receptor antibody|IP3 receptor isoform 1 antibody|IP3R 1 antibody|IP3R antibody|IP3R1 antibody|ITPR 1 antibody|Itpr1 antibody|ITPR1_HUMAN antibody|SCA15 antibody|SCA16 antibody|SCA29 antibody|Type 1 inositol 1 4 5 trisphosphate receptor antibody|Type 1 inositol 1 antibody|Type 1 InsP3 receptor antibody

Gen-ID: 3708

UniProt: Q14643

Pathways: Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, Synaptic Membrane, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma