Angiopoietin 1 Antikörper (AA 16-350)
Kurzübersicht für Angiopoietin 1 Antikörper (AA 16-350) (ABIN3043724)
Target
Alle Angiopoietin 1 (ANGPT1) Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 16-350
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Verwendungszweck
- Anti-Angiopoietin 1/ANGPT1 Antibody Picoband®
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Kreuzreaktivität (Details)
- No cross-reactivity with other proteins
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Produktmerkmale
- Anti-Angiopoietin 1/ANGPT1 Antibody Picoband® (ABIN3043724). Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
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Aufreinigung
- Immunogen affinity purified.
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Immunogen
- E.coli-derived human Angiopoietin 1 recombinant protein (Position: H16-N350). Human Angiopoietin 1 shares 96% amino acid (aa) sequence with both mouse and rat Angiopoietin 1.
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Isotyp
- IgG
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Applikationshinweise
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Western blot, 0.1-0.5 μg/mL, Human
1. "Entrez Gene: ANGPT1 angiopoietin 1". Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. 2. Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S., Sato, T. N., Yancopoulos, G. D. Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. Cell 87: 1171-1180, 1996. 3. Cheung, A. H., Stewart, R. J., Marsden, P. A. Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. Genomics 48: 389-391, 1998. -
Kommentare
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Antibody can be supported by chemiluminescence kit ABIN921124 in WB.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
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Konzentration
- 500 μg/mL
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Buffer
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Avoid repeated freezing and thawing.
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Lagerung
- 4 °C,-20 °C
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Informationen zur Lagerung
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Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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Morroniside improves microvascular functional integrity of the neurovascular unit after cerebral ischemia." in: PLoS ONE, Vol. 9, Issue 6, pp. e101194, (2014) (PubMed).
: "
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Morroniside improves microvascular functional integrity of the neurovascular unit after cerebral ischemia." in: PLoS ONE, Vol. 9, Issue 6, pp. e101194, (2014) (PubMed).
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- Angiopoietin 1 (ANGPT1)
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Andere Bezeichnung
- ANGPT1
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Hintergrund
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Synonyms: Angiopoietin-1,ANG-1,ANGPT1,KIAA0003,
Tissue Specificity: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis. .
Background: Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1. Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. Angiopoietin 1 is mapped to 8q23.1. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. Angiopoietin-1 seems to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
Sequence Similarities: Contains 1 fibrinogen C-terminal domain.
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Molekulargewicht
- 65 kDa
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Gen-ID
- 284
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UniProt
- Q15389
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Pathways
- RTK Signalweg, Glycosaminoglycan Metabolic Process
Target
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