MAFA Antikörper (Middle Region)

Produktnummer ABIN3043609

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MAFA in WB. Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für MAFA Antikörper (Middle Region) (ABIN3043609)

Target: MAFA (Transcription Factor MafA (MAFA))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAFA Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-MAFA Antikörper

Bindungsspezifität: AA 136-167, Middle Region

Verwendungszweck: Anti-Transcription factor MafA MAFA Antibody Picoband®

Sequenz: EDAVEALIGS GHHGAHHGAH HPAAAAAYEA FR

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Transcription factor MafA MAFA Antibody (ABIN3043609). Tested in WB applications. This antibody reacts with Human, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human MAFA, identical to the related mouse sequence.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human, Rat
1. Olbrot, M., Rud, J., Moss, L. G., Sharma, A. Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc. Nat. Acad. Sci. 99: 6737-6742, 2002. 2. Zhang, C., Moriguchi, T., Kajihara, M., Esaki, R., Harada, A., Shimohata, H., Oishi, H., Hamada, M., Morito, N., Hasegawa, K., Kudo, T., Engel, J. D., Yamamoto, M., Takahashi, S. MafA is a key regulator of glucose-stimulated insulin secretion. Molec. Cell. Biol. 25: 4969-4976, 2005.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu MAFA

Target: MAFA (Transcription Factor MafA (MAFA))

Andere Bezeichnung: MAFA

Hintergrund:

Synonyms: Transcription factor MafA,Pancreatic beta-cell-specific transcriptional activator,Transcription factor RIPE3b1,V-maf musculoaponeurotic fibrosarcoma oncogene homolog A,MAFA,

Background: MAFA is a transcription factor that binds RIPE3b, a conserved enhancer element that regulates pancreatic beta cell-specific expression of the insulin gene. MAFA plays a key role in coordinating and controlling the level of insulin gene expression in islet beta cells. It is located in 8q24.3. The intracellular domain of MAFA contains a single immunoreceptor tyrosine-based inhibitory motif (ITIM), which classifies MAFA as a member of an inhibitory receptor superfamily. The inhibitory capacity of MAFA is best defined in mast cells, where MAFA keeps in check the antigen-induced (i.e. Fc epsilon RI-induced) secretion ofinflammatory mediators.

Sequence Similarities: Belongs to the bZIP family. Maf subfamily.

Molekulargewicht: 37 kDa

Gen-ID: 389692

Pathways: Hormone Transport