MMP 9 Antikörper (C-Term)

Produktnummer ABIN3043582

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MMP 9 in WB, IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 67+ Publikationen erwähnt.

Kurzübersicht für MMP 9 Antikörper (C-Term) (ABIN3043582)

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP 9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Produktdetails anti-MMP 9 Antikörper

Bindungsspezifität: AA 633-667, C-Term

Verwendungszweck: Anti-MMP9 Antibody Picoband®

Sequenz: WRFDVKAQMV DPRSASEVDR MFPGVPLDTH DVFQY

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-MMP9 Antibody Picoband® (ABIN3043582). Tested in ELISA, IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MMP-9, different from the related mouse sequence by fourteen amino acids, and from the related rat sequence by sixteen amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot, 0.1-0.5 μg/mL, Human
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/mL, Human
ELISA, 0.1-0.5 μg/mL, -,
1. Template:, 92 kDa type IV collagenase). 2. Yuichiro Hirose et al. (May 2008). "A Functional Polymorphism in THBS2 that Affects Alternative Splicing and MMP Binding Is Associated with Lumbar-Disc Herniation".

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Referenzen für anti-MMP 9 Antikörper (ABIN3043582)

Liu, Li, Li, Teng, Wang, Zhang, Xiao: "TGF-β1 promotes scar fibroblasts proliferation and transdifferentiation via up-regulating MicroRNA-21." in: Scientific reports, Vol. 6, pp. 32231, (2018) (PubMed).

Li, Xiao, Li, Li, Zeng, Liu, Liang, Li, Chu, Yang: "Hydrogen sulfide reduced renal tissue fibrosis by regulating autophagy in diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1715-1722, (2018) (PubMed).

Zhao, Han, Hong, Sun: "Adipose differentiation‑related protein knockdown inhibits vascular smooth muscle cell proliferation and migration and attenuates neointima formation." in: Molecular medicine reports, Vol. 16, Issue 3, pp. 3079-3086, (2018) (PubMed).

Li, Peng, Zhang, Liu, Li, Chen, Sun, Zhu, Zhang: "Mesenchymal stem cells overexpressing adrenomedullin improve heart function through antifibrotic action in rats experiencing heart failure." in: Molecular medicine reports, Vol. 17, Issue 1, pp. 1437-1444, (2018) (PubMed).

Liu, Zeng, Wang, Li, Mastriani, Li, Bao, Zhou, Wang, Liu, Liu, Hu, Gao, Yu, Qi, Shen, Wang, Gao, Dong, Johnston, Liu: "Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9." in: Cancer biology & therapy, Vol. 18, Issue 12, pp. 990-999, (2018) (PubMed).

Bai, Luo: "5-Hydroxy-4'-Nitro-7-Propionyloxy-Genistein Inhibited Invasion and Metastasis via Inactivating Wnt/b-Catenin Signal Pathway in Human Endometrial Carcinoma Ji Endometrial Cells." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 3230-3243, (2018) (PubMed).

Xu, Hu, Khan, Shi, Cong, Li, Dai, Dai: "Argirein alleviates stress-induced and diabetic hypogonadism in rats via normalizing testis endothelin receptor A and connexin 43." in: Acta pharmacologica Sinica, Vol. 37, Issue 2, pp. 246-54, (2017) (PubMed).

Chen, Kong, Liu, Gao, Zhang, Li, Liu: "In vitro differentiation of endometrial regenerative cells into smooth muscle cells: Α potential approach for the management of pelvic organ prolapse." in: International journal of molecular medicine, Vol. 38, Issue 1, pp. 95-104, (2017) (PubMed).

Zhang, Si, Huang, Han, Liang, Xu, Wang, Li, Wang, Wang: "Preventive Effects of Rhodiola rosea L. on Bleomycin-Induced Pulmonary Fibrosis in Rats." in: International journal of molecular sciences, Vol. 17, Issue 6, (2017) (PubMed).

Li, Chen, Chen, Mo, Li, Xiao, Yu, Guo: "Circular RNA 0000096 affects cell growth and migration in gastric cancer." in: British journal of cancer, Vol. 116, Issue 5, pp. 626-633, (2017) (PubMed).

Xu, Xu, Li, Wang, Fu, Jia, Wang, Zhu, Lu, Yao: "Growth differentiation factor 15 induces growth and metastasis of human liver cancer stem-like cells via AKT/GSK-3β/β-catenin signaling." in: Oncotarget, Vol. 8, Issue 10, pp. 16972-16987, (2017) (PubMed).

Guo, Zhang, Wei, Wang, Lv, Zhang, Keller, Yao, Wang: "Cytotoxic necrotizing factor 1 promotes prostate cancer progression through activating the Cdc42-PAK1 axis." in: The Journal of pathology, Vol. 243, Issue 2, pp. 208-219, (2017) (PubMed).

Huang, Huang, Feng, Ren, Mi, Cheng, Song, Lang: "Early changes in the apparent diffusion coefficient and MMP-9 expression of a cervical carcinoma U14 allograft model following irradiation." in: Oncology letters, Vol. 14, Issue 6, pp. 6769-6775, (2017) (PubMed).

Pan, An, Meng, Li, Ren, Guan: "MgCl2 and ZnCl2 promote human umbilical vein endothelial cell migration and invasion and stimulate epithelial-mesenchymal transition via the Wnt/β-catenin pathway." in: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4663-4670, (2017) (PubMed).

Wang, Liang, Wang, Zhu, Gong, Zhang, Li, Xia: "Th17 down-regulation is involved in reduced progression of schistosomiasis fibrosis in ICOSL KO mice." in: PLoS neglected tropical diseases, Vol. 9, Issue 1, pp. e0003434, (2016) (PubMed).

Li, Luo, Liu, Fu, Xu, Wu, Shen: "Effect of Ginkgo biloba extract on experimental cardiac remodeling." in: BMC complementary and alternative medicine, Vol. 15, pp. 277, (2016) (PubMed).

Jiang, Ma, Liang, Niu, Chen, Shen: "Amniotic Mesenchymal Stem Cells Can Enhance Angiogenic Capacity via MMPs In Vitro and In Vivo." in: BioMed research international, Vol. 2015, pp. 324014, (2016) (PubMed).

Han, Wang, Huang, Cheng, Sun, Chen, Xie, Zhou, Du: "Isolation and characteristics of CD133‑/A2B5+ and CD133‑/A2B5‑ cells from the SHG139s cell line." in: Molecular medicine reports, Vol. 12, Issue 6, pp. 7949-56, (2016) (PubMed).

Fan, Jiang, Li, Fang, Xu, Zheng: "MMP-1/2 and TIMP-1/2 expression levels, and the levels of collagenous and elastic fibers correlate with disease progression in a hamster model of tongue cancer." in: Oncology letters, Vol. 11, Issue 1, pp. 63-68, (2016) (PubMed).

Wang, Qiu, Ren: "Inhibition of acute lung injury by rubriflordilactone in LPS-induced rat model through suppression of inflammatory factor expression." in: International journal of clinical and experimental pathology, Vol. 8, Issue 12, pp. 15954-9, (2016) (PubMed).

Details zu MMP 9

Target: MMP 9 (MMP9) (Matrix Metallopeptidase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa Type IV Collagenase) (MMP9))

Andere Bezeichnung: MMP9

Hintergrund:

Synonyms: Matrix metalloproteinase-9,MMP-9,3.4.24.35,92 kDa gelatinase,92 kDa type IV collagenase,Gelatinase B,GELB,67 kDa matrix metalloproteinase-9,82 kDa matrix metalloproteinase-9,MMP9,CLG4B,

Tissue Specificity: Produced by normal alveolar macrophages and granulocytes.

Background: Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is an enzyme that in humans is encoded by the MMP9 gene. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling.

Molekulargewicht: 79 kDa

Gen-ID: 4318

UniProt: P14780

Pathways: Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events