OPA1 Antikörper (C-Term)

Produktnummer ABIN3043457

Produktdetails anti-OPA1 Antikörper

Target: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Bindungsspezifität: AA 919-955, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser OPA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Verwendungszweck: Rabbit IgG polyclonal antibody for Dynamin-like 120 kDa protein, mitochondrial(OPA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.

Sequenz: EDGEKKIKLL TGKRVQLAED LKKVREIQEK LDAFIEA

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Dynamin-like 120 kDa protein, mitochondrial(OPA1) detection. Tested with WB, IHC-P in Human,Mouse,Rat.
Gene Name: optic atrophy 1 (autosomal dominant)
Protein Name: Dynamin-like 120 kDa protein, mitochondrial

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human OPA1 (919-955aa EDGEKKIKLLTGKRVQLAEDLKKVREIQEKLDAFIEA), different from the related mouse and rat sequences by one amino acid.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Mouse, Rat, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
Notes: Tested Species: Species with positive results. Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Details zu OPA1

Target: OPA1 (Optic Atrophy 1 (Autosomal Dominant) (OPA1))

Andere Bezeichnung: OPA1 (OPA1 Produkte)

Hintergrund: Dynamin-like 120 kDa protein, mitochondrial is a protein that in humans is encoded by the OPA1 gene. It is mapped to 3q29. This protein regulates mitochondrial fusion and cristae structure in the inner mitochondrial membrane (IMM) and contributes to ATP synthesis and apoptosis. This gene product is a nuclear-encoded mitochondrial protein with similarity to dynamin-related GTPases. It is a component of the mitochondrial network. Mutations in this gene have been associated with optic atrophy type 1, which is a dominantly inherited optic neuropathy resulting in progressive loss of visual acuity, leading in many cases to legal blindness. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms: Dynamin like 120 kDa protein antibody|Dynamin like 120 kDa protein, mitochondrial antibody|Dynamin-like 120 kDa protein, form S1 antibody|FLJ12460 antibody|Juvenile kjer type optic atrophy antibody|KIAA0567 antibody|KJER type antibody|Large GTP binding protein antibody|largeG antibody|MGM1 antibody|Mitochondrial dynamin like 120 kDa protein antibody|Mitochondrial dynamin like GTPase antibody| NPG antibody|NTG antibody|OAK antibody|OPA 1 antibody|opa1 antibody|OPA1 gene antibody|OPA1_HUMAN antibody|Optic atrophy 1 (autosomal dominant) antibody|OPTIC ATROPHY 1 antibody|Optic atrophy 1 gene protein antibody|Optic atrophy 1 homolog (human) antibody| Optic atrophy protein 1 antibody|Optic atrophy protein 1 homolog antibody|

Gen-ID: 4976

UniProt: O60313

Pathways: Tube Formation