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PKC eta Antikörper (AA 30-389)

PRKCH Reaktivität: Human WB, IHC, ICC, FACS Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043361
  • Target Alle PKC eta (PRKCH) Antikörper anzeigen
    PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
    Bindungsspezifität
    • 10
    • 10
    • 7
    • 5
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 30-389
    Reaktivität
    • 48
    • 25
    • 16
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    Human
    Wirt
    • 53
    • 3
    Kaninchen
    Klonalität
    • 53
    • 3
    Polyklonal
    Konjugat
    • 35
    • 7
    • 6
    • 4
    • 2
    • 2
    Dieser PKC eta Antikörper ist unkonjugiert
    Applikation
    • 47
    • 34
    • 20
    • 15
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Verwendungszweck
    Anti-PKC eta/PRKCH Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-PKC eta/PRKCH Antibody Picoband® (ABIN3043361). Tested in Flow Cytometry, IHC, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human PKC eta recombinant protein (Position: R30-D389). Human PKC eta shares 96.7% and 96.1% amino acid (aa) sequence identity with mouse and rat PKC eta, respectively.
    Isotyp
    IgG
    Top Product
    Discover our top product PRKCH Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human
    Immunohistochemistry (Frozen Section), 0.5-1 μg/mL, Human
    Immunocytochemistry, 0.5-1 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. "Entrez Gene: PRKCH protein kinase C, eta". 2. Bacher N, Zisman Y, Berent E, Livneh E (Apr 1992). "Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart". Mol Cell Biol 12 (3): 1404.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Gan, Wang, Zhao, Wu, Yang, Peng: "5-(Bis(3-(2-hydroxyethyl)-1H-indol-2-yl)methyl)-2-hydroxybenzoic acid (BHIMHA): showing a strategy of designing drug to block lung metastasis of tumors." in: Drug design, development and therapy, Vol. 10, pp. 711-21, (2016) (PubMed).

  • Target
    PKC eta (PRKCH) (Protein Kinase C, eta (PRKCH))
    Andere Bezeichnung
    PRKCH (PRKCH Produkte)
    Hintergrund

    Synonyms: Protein kinase C eta type,2.7.11.13,PKC-L,nPKC-eta,PRKCH,PKCL, PRKCL,

    Tissue Specificity: Most abundant in lung, less in heart and skin. .

    Background: PRKCH is also known as PKC eta. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. Also, PKC family members serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. And it is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene.

    Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.

    Molekulargewicht
    78 kDa
    Gen-ID
    5583
    UniProt
    P24723
    Pathways
    Myometrial Relaxation and Contraction, Thromboxane A2 Receptor Signaling
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