SERPINB2 Antikörper (AA 1-180)

Produktnummer ABIN3043329

Dieses Anti-SERPINB2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SERPINB2 in WB und IHC. Geeignet für Human.

Kurzübersicht für SERPINB2 Antikörper (AA 1-180) (ABIN3043329)

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SERPINB2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-SERPINB2 Antikörper

Bindungsspezifität: AA 1-180

Verwendungszweck: Anti-SerpinB2 Antibody Picoband®

Kreuzreaktivität (Details): No cross-reactivity with other proteins.

Produktmerkmale: Anti-SerpinB2 Antibody Picoband® (ABIN3043329). Tested in IHC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: E.coli-derived human SerpinB2 recombinant protein (Position: M1-K180). Human SerpinB2 shares 70% and 66% amino acid (aa) sequence identity with mouse and rat SerpinB2, respectively.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
Western blot, 0.1-0.5 μg/mL, Human
1. Corsetti JP, et al. Plasminogen activator inhibitor-2 polymorphism associates with recurrent coronary event risk in patients with high HDL and C-reactive protein levels. PLoS One, 2013. 2. Huang Z, et al. SERPINB2 down-regulation contributes to chemoresistance in head and neck cancer. Mol Carcinog, 2014 Oct. 3. Jin Y, et al. Expression of plasminogen activator inhibitor-2 is negatively associated with invasive potential in hepatocellular carcinoma cells. Chin Med Sci J, 2013 Mar. 4. Zhou L, et al. Low expression of PAI-2 as a novel marker of portal vein tumor thrombosis and poor prognosis in hepatocellular carcinoma. World J Surg, 2013 Mar.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu SERPINB2

Target: SERPINB2 (Plasminogen Activator Inhibitor 2 (SERPINB2))

Andere Bezeichnung: SERPINB2

Substanzklasse: Amino Acid

Hintergrund:

Synonyms: Plasminogen activator inhibitor 2,PAI-2,Monocyte Arg-serpin,Placental plasminogen activator inhibitor,Serpin B2,Urokinase inhibitor,SERPINB2,PAI2, PLANH2,

Tissue Specificity: Plasma. .

Background: SERPINB2 is also known as PAI or PAI2. Plasminogen activator inhibitor-2 (placental PAI) is acoagulation factor that inactivates tPA and urokinase. It is present in most cells, especially monocytes/macrophages. PAI-2 exists in two forms, a 60- kDa extracellular glycosylated form and a 43- kDa intracellular form. It is present only at detectable quantities in blood during pregnancy, as it is produced by the placenta, and may explain partially the increased rate of thrombosisduring pregnancy. The majority of expressed PAI-2 remains unsecreted due to the presence of an inefficient internal signal peptide.

Sequence Similarities: Belongs to the semaphorin family.

Molekulargewicht: 47 kDa

Gen-ID: 5055

UniProt: P05120

Pathways: Autophagie