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TJP1 Antikörper (AA 1178-1527)

TJP1 Reaktivität: Human, Maus, Ratte WB, IHC, IF, FACS, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043312
  • Target Alle TJP1 Antikörper anzeigen
    TJP1 (Tight Junction Protein 1 (TJP1))
    Bindungsspezifität
    • 15
    • 6
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1178-1527
    Reaktivität
    • 58
    • 35
    • 33
    • 18
    • 17
    • 8
    • 5
    • 5
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 54
    • 3
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 55
    • 6
    Polyklonal
    Konjugat
    • 38
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TJP1 Antikörper ist unkonjugiert
    Applikation
    • 50
    • 21
    • 18
    • 17
    • 15
    • 13
    • 12
    • 11
    • 10
    • 8
    • 8
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunocytochemistry (ICC)
    Verwendungszweck
    Anti-ZO1 tight junction protein/TJP1 Antibody Picoband®
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-ZO1 tight junction protein/TJP1 Antibody Picoband® (ABIN3043312). Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    E.coli-derived human TJP1 recombinant protein (Position: H1178-F1527). Human TJP1 shares 82% amino acid (aa) sequence identity with mouse TJP1.
    Isotyp
    IgG
    Top Product
    Discover our top product TJP1 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Human
    Immunocytochemistry/Immunofluorescence, 2 μg/mL, Human
    Flow Cytometry (Fixed), 1-3 μg/1x106 cells, Human1. Mohandas TK, Chen XN, Rowe LB, Birkenmeier EH, Fanning AS, Anderson JM, Korenberg JR (February 1997). "Localization of the tight junction protein gene TJP1 to human chromosome 15q13, distal to the Prader-Willi/Angelman region, and to mouse chromosome 7". Genomics 30 (3): 594-7. 2. Willott, E., Balda, M. S., Fanning, A. S., Jameson, B., Van Itallie, C., Anderson, J. M. The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc. Nat. Acad. Sci. 90: 7834-7838, 1993.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Liu, Mei, Xu, Yu, Shi, Zhang, Wang, Zhang, Gao, Zhang, He: "Dual Receptor Recognizing Cell Penetrating Peptide for Selective Targeting, Efficient Intratumoral Diffusion and Synthesized Anti-Glioma Therapy." in: Theranostics, Vol. 6, Issue 2, pp. 177-91, (2017) (PubMed).

    Subramani, Ponnalagu, Krishna, Jeyabalan, Chevour, Sharma, Jayadev, Shetty, Begum, Archunan, Das: "Resveratrol reverses the adverse effects of bevacizumab on cultured ARPE-19 cells." in: Scientific reports, Vol. 7, Issue 1, pp. 12242, (2017) (PubMed).

    Lv, Phuong, Jin, Li, Xu: "Protection by simvastatin on hyperglycemia-induced endothelial dysfunction through inhibiting NLRP3 inflammasomes." in: Oncotarget, Vol. 8, Issue 53, pp. 91291-91305, (2017) (PubMed).

    Wen, Huang, Zhang, Zhang, Chen, Gu, Hao: "Resveratrol attenuates diabetic nephropathy via modulating angiogenesis." in: PLoS ONE, Vol. 8, Issue 12, pp. e82336, (2013) (PubMed).

  • Target
    TJP1 (Tight Junction Protein 1 (TJP1))
    Andere Bezeichnung
    TJP1 (TJP1 Produkte)
    Hintergrund

    Synonyms: Tight junction protein ZO-1,Tight junction protein 1,Zona occludens protein 1,Zonula occludens protein 1,TJP1,ZO1,

    Tissue Specificity: The alpha-containing isoform is found in most epithelial cell junctions. The short isoform is found both in endothelial cells and the highly specialized epithelial junctions of renal glomeruli and Sertoli cells of the seminiferous tubules.

    Background: Tight junction protein ZO-1 is a protein that in humans is encoded by the TJP1 gene. It is mapped to 15q13.1. This gene encodes a protein located on a cytoplasmic membrane surface of intercellular tight junctions. The encoded protein may be involved in signal transduction at cell-cell junctions. It has been found that injected CagA associates with the epithelial tight-junction scaffolding protein TJP1 and the transmembrane protein junctional adhesion molecule, causing an ectopic assembly of tight junction components at sites of bacterial attachment, and altering the composition and function of the apical-junctional complex.

    Sequence Similarities: Belongs to the MAGUK family.

    Molekulargewicht
    220 kDa
    Gen-ID
    7082
    UniProt
    Q07157
    Pathways
    Carbohydrate Homeostasis, Cell-Cell Junction Organization
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