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SRSF1 Antikörper (N-Term)

Dieses Anti-SRSF1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SRSF1 in WB und IHC. Geeignet für Human, Maus und Ratte.
Produktnummer ABIN3043296

Kurzübersicht für SRSF1 Antikörper (N-Term) (ABIN3043296)

Target

Alle SRSF1 Antikörper anzeigen
SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

Reaktivität

  • 55
  • 29
  • 29
  • 7
  • 7
  • 5
  • 5
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 52
  • 3
Kaninchen

Klonalität

  • 43
  • 12
Polyklonal

Konjugat

  • 33
  • 4
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Dieser SRSF1 Antikörper ist unkonjugiert

Applikation

  • 36
  • 16
  • 14
  • 10
  • 7
  • 7
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 8
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 6-33, N-Term

    Verwendungszweck

    Anti-SF2/SRSF1 Antibody Picoband®

    Sequenz

    VIRGPAGNND CRIYVGNLPP DIRTKDIE

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins.

    Produktmerkmale

    Anti-SF2/SRSF1 Antibody Picoband® (ABIN3043296). Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the N-terminus of Human SF2, identical to the related mouse sequence.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse, Rat
    Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/mL, Human, Mouse, Rat
    1. "Entrez Gene: SFRS1 splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate splicing factor)". 2. Michlewski G, Sanford JR, Cáceres JF (April 2008). "The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1". Mol. Cell 30 (2): 179-89. 3. Zuo P, Manley JL (December 1993)."Functional domains of the human splicing factor ASF/SF2". EMBO J. 12 (12): 4727-37.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
  • Target

    SRSF1 (serine/arginine-Rich Splicing Factor 1 (SRSF1))

    Andere Bezeichnung

    SRSF1

    Hintergrund

    Synonyms: Serine/arginine-rich splicing factor 1,Alternative-splicing factor 1,ASF-1,Splicing factor, arginine/serine-rich 1,pre-mRNA-splicing factor SF2, P33 subunit,SRSF1,ASF, SF2, SF2P33, SFRS1,OK/SW-cl.3,

    Tissue Specificity: Mainly expressed in the developing central nervous system.

    Background: SF2, also known as Serine/arginine-rich splicing factor 1 (SRSF1), is a protein that in humans is encoded by the SFRS1 gene. This gene encodes a member of the arginine/serine-rich splicing factor protein family. There is a pseudogene of this gene on chromosome 13. The encoded protein can either activate or repress splicing, depending on its phosphorylation state and its interaction partners. Multiple transcript variants have been found for this gene. ASF/SF2 is necessary for all splicing reactions to occur, and influences splice site selection in a concentration-dependent manner, resulting in alternative splicing.

    Sequence Similarities: Belongs to the splicing factor SR family.

    Molekulargewicht

    28 kDa

    Gen-ID

    6426

    UniProt

    Q07955

    Pathways

    Ribonucleoprotein Complex Subunit Organization
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