KNG1 Antikörper (Middle Region)

Produktnummer ABIN3043285

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch KNG1 in WB und IHC. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für KNG1 Antikörper (Middle Region) (ABIN3043285)

Target: KNG1 (Kininogen 1 (KNG1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KNG1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-KNG1 Antikörper

Bindungsspezifität: AA 227-259, Middle Region

Verwendungszweck: Anti-Kininogen 1/KNG1 Antibody Picoband®

Sequenz: ECRGNLFMDI NNKIANFSQS CTLYSGDDLV EA

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Kininogen 1/KNG1 Antibody Picoband® (ABIN3043285). Tested in IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of mouse Kininogen 1, different from the related rat sequence by thirteen amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse
Western blot, 0.1-0.5 μg/mL, Mouse
1. "Entrez Gene: kininogen 1". 2. Fong, D., Smith, D. I., Hsieh, W.-T. The human kininogen gene (KNG) mapped to chromosome 3q26-qter by analysis of somatic cell hybrids using the polymerase chain reaction. Hum. Genet. 87: 189-192, 1991.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Details zu KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Andere Bezeichnung: Kng1

Hintergrund:

Synonyms: Kininogen-1,Kininogen-1 heavy chain,Bradykinin,Kininogen-1 light chain,Kng1,Kng,

Tissue Specificity: Plasma.

Background: Kininogen-1 (KNG1), also known as BDK or bradykinin, is a protein that in humans is encoded by the KNG1 gene. It is mapped to 3q27.3. The KNG1 gene uses alternative splicing to generate two different proteins - high - molecular - weight kininogen (HMWK) and low - molecular- weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, KNG1, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. In addition to that, KNG1 is a constituent of the blood coagulation system as well as the kinin-kallikrein system.

Sequence Similarities: Contains 1 HMG box DNA-binding domain.

Molekulargewicht: 73 kDa

Gen-ID: 16644

UniProt: O08677

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process