Resistin Antikörper (C-Term)

Produktnummer ABIN3043196

Der Kaninchen Polyklonal Anti-Resistin-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Resistin in Proben von Maus zu detektieren.

Kurzübersicht für Resistin Antikörper (C-Term) (ABIN3043196)

Target: Resistin (RETN)

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Resistin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Resistin Antikörper

Bindungsspezifität: AA 93-114, C-Term

Verwendungszweck: Anti-Resistin/RETN Antibody Picoband®

Sequenz: CHCQCARIDW TAARCCKLQV AS

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Resistin/RETN Antibody (ABIN3043196). Tested in IHC, WB applications. This antibody reacts with Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Resistin.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Mouse
Western blot, 0.1-0.5 μg/mL, Mouse
1. Holcomb, I. N., Kabakoff, R. C., Chan, B., Baker, T. W., Gurney, A., Henzel, W., Nelson, C., Lowman, H. B., Wright, B. D., Skelton, N. J., Frantz, G. D., Tumas, D. B., Peale, F. V., Jr., Shelton, D. L., Hebert, C. C.FIZZ1, a novel cysteine-rich secreted protein associated with pulmonary inflammation, defines a new gene family.EMBO J. 19: 4046-4055, 2000. 2. Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., Lazar, M. A.The hormone resistin links obesity to diabetes.Nature 409: 307-312, 2001. 3. Wang, H., Chu, W. S., Hemphill, C., Elbein, S. C.Human resistin gene: molecular scanning and evaluation of association with insulin sensitivity and type 2 diabetes in Caucasians.J. Clin. Endocr. Metab. 87: 2520-2524, 2002.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Resistin

Target: Resistin (RETN)

Andere Bezeichnung: RETN

Hintergrund:

Synonyms: Resistin,Adipose tissue-specific secretory factor,ADSF,Adipose-specific cysteine-rich secreted protein A12-alpha,Cysteine-rich secreted protein FIZZ3,Retn,Fizz3,

Tissue Specificity: Expressed in white but not brown adipose tissue in a variety of organs.

Background: Resistin, also known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) is a cysteine-rich protein that in humans is encoded by the RETN gene. The resistin gene comprises 4 exons, the first of which is untranslated, and spans approximately 1,750 bp. The human resistin gene is localized to a cloned fragment of human chromosome 19. In primates, pigs and dogs, resistin is secreted by immune and epithelial cells while in rodents, it is secreted by adipose tissue. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus.

Sequence Similarities: Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.

Molekulargewicht: 38 kDa

UniProt: Q99P87

Pathways: Feeding Behaviour, Smooth Muscle Cell Migration