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Kallikrein 5 Antikörper (C-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Kallikrein 5 in WB und IHC. Er zeigt eine Reaktivität gegenüber Maus und Ratte.
Produktnummer ABIN3043138

Kurzübersicht für Kallikrein 5 Antikörper (C-Term) (ABIN3043138)

Target

Alle Kallikrein 5 (KLK5) Antikörper anzeigen
Kallikrein 5 (KLK5)

Reaktivität

  • 33
  • 16
  • 4
Maus, Ratte

Wirt

  • 30
  • 8
  • 1
Kaninchen

Klonalität

  • 30
  • 9
Polyklonal

Konjugat

  • 28
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser Kallikrein 5 Antikörper ist unkonjugiert

Applikation

  • 23
  • 13
  • 12
  • 6
  • 6
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 278-293, C-Term

    Verwendungszweck

    Anti-Kallikrein 5/KLK5 Antibody Picoband®

    Sequenz

    NLCEFVKWIK DTMNSN

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-Kallikrein 5/KLK5 Antibody (ABIN3043138). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 5, different from the related rat sequence by three amino acids.

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
    Western blot, 0.1-0.5 μg/mL, Mouse
    1. Brattsand, M., Egelrud, T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274: 30033-30040, 1999. 2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 3. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Kallikrein 5 (KLK5)

    Andere Bezeichnung

    KLK5

    Hintergrund

    Synonyms: Kallikrein 1-related peptidase b5 ,Kallikrein related-peptidase 5 ,Klk5 ,

    Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells, isoform beta-3C is specifically expressed in prostate and testis.

    Background: KLK5 (Kallikrein-related peptidase 5), formerly known as stratum corneum tryptic enzyme (SCTE) or KLKL2, is a serine protease expressed in the epidermis. The KLK5 gene is one of the fifteen kallikrein subfamily members which is located on 19q13.41. KLK5 has been suggested to regulate cell shedding in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. The KLK5 gene contains 5 coding exons spanning 9.3. KLK5 expression is upregulated in a breast cancer cell line in the presence of estrogens and progestins and is associated with more aggressive forms of epithelial ovarian carcinoma.

    Sequence Similarities: Belongs to the integrin beta chain family.

    Molekulargewicht

    29 kDa

    UniProt

    Q9D140

    Pathways

    Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling
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