Kallikrein 5 Antikörper (C-Term)

Produktnummer ABIN3043138

Produktdetails anti-Kallikrein 5 Antikörper

Target: Kallikrein 5 (KLK5)

Bindungsspezifität: AA 278-293, C-Term

Reaktivität: Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Kallikrein 5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Verwendungszweck: Anti-Kallikrein 5/KLK5 Antibody Picoband®

Sequenz: NLCEFVKWIK DTMNSN

Kreuzreaktivität (Details): No cross-reactivity with other proteins

Produktmerkmale: Anti-Kallikrein 5/KLK5 Antibody (ABIN3043138). Tested in IHC, WB applications. This antibody reacts with Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of mouse Kallikrein 5, different from the related rat sequence by three amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry (Paraffin-embedded Section), 0.5-1 μg/mL, Rat, Mouse
Western blot, 0.1-0.5 μg/mL, Mouse
1. Brattsand, M., Egelrud, T. Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J. Biol. Chem. 274: 30033-30040, 1999. 2. Elliott, M. B., Irwin, D. M., Diamandis, E. P. In silico identification and Bayesian phylogenetic analysis of multiple new mammalian kallikrein gene families. Genomics 88: 591-599, 2006. 3. Gan, L., Lee, I., Smith, R., Argonza-Barrett, R., Lei, H., McCuaig, J., Moss, P., Paeper, B., Wang, K. Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region. Gene 257: 119-130, 2000.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P).

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu Kallikrein 5

Target: Kallikrein 5 (KLK5)

Andere Bezeichnung: KLK5 (KLK5 Produkte)

Hintergrund:

Synonyms: Kallikrein 1-related peptidase b5 ,Kallikrein related-peptidase 5 ,Klk5 ,

Tissue Specificity: Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells, isoform beta-3C is specifically expressed in prostate and testis.

Background: KLK5 (Kallikrein-related peptidase 5), formerly known as stratum corneum tryptic enzyme (SCTE) or KLKL2, is a serine protease expressed in the epidermis. The KLK5 gene is one of the fifteen kallikrein subfamily members which is located on 19q13.41. KLK5 has been suggested to regulate cell shedding in conjunction with KLK7 and KLK14, given its ability to degrade proteins which form the extracellular component of cell junctions in the stratum corneum. The KLK5 gene contains 5 coding exons spanning 9.3. KLK5 expression is upregulated in a breast cancer cell line in the presence of estrogens and progestins and is associated with more aggressive forms of epithelial ovarian carcinoma.

Sequence Similarities: Belongs to the integrin beta chain family.

Molekulargewicht: 29 kDa

UniProt: Q9D140

Pathways: Komplementsystem, Regulation of G-Protein Coupled Receptor Protein Signaling