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Patched 2 Antikörper (C-Term)

Dieses Anti-Patched 2-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Patched 2 in WB. Geeignet für Human und Maus.
Produktnummer ABIN3043014

Kurzübersicht für Patched 2 Antikörper (C-Term) (ABIN3043014)

Target

Alle Patched 2 (PTCH2) Antikörper anzeigen
Patched 2 (PTCH2)

Reaktivität

  • 16
  • 4
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Maus

Wirt

  • 15
  • 1
Kaninchen

Klonalität

  • 15
  • 1
Polyklonal

Konjugat

  • 12
  • 2
  • 1
  • 1
Dieser Patched 2 Antikörper ist unkonjugiert

Applikation

  • 11
  • 8
  • 5
  • 3
  • 3
  • 2
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 885-901, C-Term

    Verwendungszweck

    Anti-PTCH2 Antibody Picoband®

    Sequenz

    WLHDKYDTTG ENLRIPP

    Kreuzreaktivität (Details)

    No cross-reactivity with other proteins

    Produktmerkmale

    Anti-PTCH2 Antibody (ABIN3043014). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

    Aufreinigung

    Immunogen affinity purified.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2, different from the related mouse sequence by one amino acid.

    Isotyp

    IgG
  • Applikationshinweise

    Western blot, 0.1-0.5 μg/mL, Human, Mouse
    1. Nieuwenhuis, E., Motoyama, J., Barnfield, P. C., Yoshikawa, Y., Zhang, X., Mo, R., Crackower, M. A., Hui, C. Mice with a targeted mutation of Patched 2 are viable but develop alopecia and epidermal hyperplasia. Molec. Cell. Biol. 26: 6609-6622, 2006.

    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

    Konzentration

    500 μg/mL

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Thimerosal (Merthiolate), Sodium azide

    Vorsichtsmaßnahmen

    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

    Haltbarkeit

    12 months
  • Target

    Patched 2 (PTCH2)

    Andere Bezeichnung

    PTCH2

    Hintergrund

    Synonyms: Protein patched homolog 2;PTC2;PTCH2;UNQ560/PRO1121/PRO57079;

    Tissue Specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .

    Background: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling.

    Sequence Similarities: Belongs to the patched family.

    Molekulargewicht

    50 kDa

    UniProt

    Q9Y6C5

    Pathways

    Hedgehog Signalweg
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