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Patched 2 Antikörper (C-Term)

PTCH2 Reaktivität: Human, Maus WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN3043014
  • Target Alle Patched 2 (PTCH2) Antikörper anzeigen
    Patched 2 (PTCH2)
    Bindungsspezifität
    • 5
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 885-901, C-Term
    Reaktivität
    • 14
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 13
    • 1
    Kaninchen
    Klonalität
    • 13
    • 1
    Polyklonal
    Konjugat
    • 10
    • 2
    • 1
    • 1
    Dieser Patched 2 Antikörper ist unkonjugiert
    Applikation
    • 9
    • 7
    • 4
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB)
    Verwendungszweck
    Anti-PTCH2 Antibody Picoband®
    Sequenz
    WLHDKYDTTG ENLRIPP
    Kreuzreaktivität (Details)
    No cross-reactivity with other proteins
    Produktmerkmale
    Anti-PTCH2 Antibody (ABIN3043014). Tested in WB applications. This antibody reacts with Human, Mouse. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.
    Aufreinigung
    Immunogen affinity purified.
    Immunogen
    A synthetic peptide corresponding to a sequence at the C-terminus of human PTCH2, different from the related mouse sequence by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product PTCH2 Primärantikörper
  • Applikationshinweise
    Western blot, 0.1-0.5 μg/mL, Human, Mouse
    1. Nieuwenhuis, E., Motoyama, J., Barnfield, P. C., Yoshikawa, Y., Zhang, X., Mo, R., Crackower, M. A., Hui, C. Mice with a targeted mutation of Patched 2 are viable but develop alopecia and epidermal hyperplasia. Molec. Cell. Biol. 26: 6609-6622, 2006.
    Kommentare

    Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.
    Konzentration
    500 μg/mL
    Buffer
    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
    Konservierungsmittel
    Thimerosal (Merthiolate), Sodium azide
    Vorsichtsmaßnahmen
    This product contains Thimerosal (Merthiolate) and Sodium azide: POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.
    Handhabung
    Avoid repeated freezing and thawing.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
    It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Patched 2 (PTCH2)
    Andere Bezeichnung
    PTCH2 (PTCH2 Produkte)
    Hintergrund

    Synonyms: Protein patched homolog 2;PTC2;PTCH2;UNQ560/PRO1121/PRO57079;

    Tissue Specificity: Bone marrow, testis and kidney. Isoform 4 is detected in all bladder tumor and prostate tumor cells. .

    Background: PTCH2 (patched 2), also known as PTC2, encodes a 1.203-amino acid putative transmembrane protein that is highly homologous to the PTCH product. The Patched-hedgehog signaling pathway is involved in establishing segment polarity and the anterior-posterior orientation of a number of developing appendages. The pathway is conserved from fly to vertebrates and has been implicated in a number of human neoplasms and developmental syndromes. Mutations in the human Patched gene are the basis of the nevoid basal cell carcinoma syndrome. With age, homozygous mutant male mice developed skin lesions consisting of alopecia and epidermal hyperplasia, suggesting a role for Ptch2 in adult epidermal homeostasis via Shh signaling.

    Sequence Similarities: Belongs to the patched family.

    Molekulargewicht
    50 kDa
    UniProt
    Q9Y6C5
    Pathways
    Hedgehog Signalweg
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