FLT1 Antikörper (N-Term)

Produktnummer ABIN3042978

Produktdetails anti-FLT1 Antikörper

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Bindungsspezifität: AA 278-298, N-Term

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FLT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Verwendungszweck: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor receptor 1(FLT1) detection. Tested with WB in Rat.

Sequenz: IRQRIDQSNP HSNVFHSVLK I

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Vascular endothelial growth factor receptor 1(FLT1) detection. Tested with WB in Rat.
Gene Name: fms-related tyrosine kinase 1
Protein Name: Vascular endothelial growth factor receptor 1

Aufreinigung: Immunogen affinity purified.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of rat FLT1(278-298aa IRQRIDQSNPHSNVFHSVLKI).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Rat, The detection limit for FLT1 is approximately 0.5 ng/lane under reducing conditions.
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities.
Other applications have not been tested. Optimal dilutions should be determined by end users.

Kommentare:

Antibody can be supported by chemiluminescence kit ABIN921124 in WB.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Konzentration: 500 μg/mL

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.

Haltbarkeit: 12 months

Referenzen für anti-FLT1 Antikörper (ABIN3042978)

Liu, Kuang, Wu, Jin, Sun: "A novel polysaccharide from Sargassum integerrimum induces apoptosis in A549 cells and prevents angiogensis in vitro and in vivo." in: Scientific reports, Vol. 6, pp. 26722, (2018) (PubMed).

Wu, You, Ma, Li, Yuan, Li, Ye, Liu, Yao, Chen, Lai, Yang: "Role of transient receptor potential ion channels and evoked levels of neuropeptides in a formaldehyde-induced model of asthma in BALB/c mice." in: PLoS ONE, Vol. 8, Issue 5, pp. e62827, (2013) (PubMed).

Details zu FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Andere Bezeichnung: FLT1 (FLT1 Produkte)

Hintergrund: Vascular endothelial growth factor receptor 1(FLT1) is a protein that in humans is encoded by the FLT1 gene. Oncogene FLT belongs to the src gene family. It is mapped to 13q12. The deduced 1,338-amino acid protein has a calculated molecular mass of 150.6 kD. It has a 758-amino acid extracellular domain, followed by a 22-amino acid transmembrane region and a 558-amino acid cytoplasmic region containing a cluster of basic amino acids and a tyrosine kinase domain. sFLT-1 was identified in placenta, adult lung, kidney, liver and uterus. Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation.

Synonyms: EC 2.7.10.1 antibody|Flt 1 antibody|FLT antibody|Flt-1 antibody|Flt1 antibody|Fms like tyrosine kinase 1 antibody|Fms related tyrosine kinase 1(vascular endothelial growth factor/vascular permeability factor receptor) antibody|Fms related tyrosine kinase 1 antibody|Fms related tyrosine kinase 1 vascular endothelial growth factor/vascular permeability factor receptor antibody|Fms-like tyrosine kinase 1 antibody|FRT antibody|Soluble VEGF receptor 1 14 antibody|Soluble VEGFR1 variant 2 antibody|Soluble VEGFR1 variant 21 antibody|Tyrosine protein kinase FRT antibody|Tyrosine protein kinase receptor FLT antibody|Tyrosine-protein kinase FRT antibody|Tyrosine-protein kinase receptor FLT antibody|Vascular endothelial growth factor receptor 1 antibody|Vascular endothelial growth factor receptor 1 Precursor antibody|Vascular endothelial growth factor vascular permeability factor receptor antibody|Vascular permeability factor receptor 1 antibody|Vascular permeability factor receptor antibody|VEGFR 1 antibody|VEGFR-1 antibody|VEGFR1 antibody|VGFR1_HUMAN antibody

UniProt: P53767

Pathways: RTK Signalweg, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals